TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent reg...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02583-3 |
| _version_ | 1830199606903832576 |
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| author | Maren Hülsemann Colline Sanchez Polina V. Verkhusha Vera Des Marais Serena P. H. Mao Sara K. Donnelly Jeffrey E. Segall Louis Hodgson |
| author_facet | Maren Hülsemann Colline Sanchez Polina V. Verkhusha Vera Des Marais Serena P. H. Mao Sara K. Donnelly Jeffrey E. Segall Louis Hodgson |
| author_sort | Maren Hülsemann |
| collection | DOAJ |
| description | Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent regulation of spatiotemporal TC10 activity. |
| first_indexed | 2024-12-18T02:15:54Z |
| format | Article |
| id | doaj.art-608534c3193740aaa779560f505d5296 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-18T02:15:54Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-608534c3193740aaa779560f505d52962022-12-21T21:24:22ZengNature PortfolioCommunications Biology2399-36422021-09-014112310.1038/s42003-021-02583-3TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodiaMaren Hülsemann0Colline Sanchez1Polina V. Verkhusha2Vera Des Marais3Serena P. H. Mao4Sara K. Donnelly5Jeffrey E. Segall6Louis Hodgson7Department of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineDepartment of Anatomy and Structural Biology, Albert Einstein College of MedicineHülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent regulation of spatiotemporal TC10 activity.https://doi.org/10.1038/s42003-021-02583-3 |
| spellingShingle | Maren Hülsemann Colline Sanchez Polina V. Verkhusha Vera Des Marais Serena P. H. Mao Sara K. Donnelly Jeffrey E. Segall Louis Hodgson TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia Communications Biology |
| title | TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia |
| title_full | TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia |
| title_fullStr | TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia |
| title_full_unstemmed | TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia |
| title_short | TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia |
| title_sort | tc10 regulates breast cancer invasion and metastasis by controlling membrane type 1 matrix metalloproteinase at invadopodia |
| url | https://doi.org/10.1038/s42003-021-02583-3 |
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