Haematological Changes in Patients with Human Tuberculosis.
Some haematological alterations due to active cases of tuberculosis caused by Mycobacterium tuberculosis were investigated in Enugu Urban of South East, Nigeria. The results revealed thrombocythaemia, leucocytosis and elevated Erythrocyte sedimentation rates (p and lt;0.05). There was oligocythaemia...
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| Format: | Article |
| Language: | English |
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Enugu State University of Science and Technology, ESUT, Enugu, Nigeria.
2017-06-01
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| Series: | Journal of Experimental Research |
| Online Access: | http://www.er-journal.com/papers/Okafor AI_June_2017_28-32.pdf |
| Summary: | Some haematological alterations due to active cases of tuberculosis caused by Mycobacterium tuberculosis were investigated in Enugu Urban of South East, Nigeria. The results revealed thrombocythaemia, leucocytosis and elevated Erythrocyte sedimentation rates (p and lt;0.05). There was oligocythaemia, as well as reduced haematocrit and haemoglobin concentrations (p and lt;0.05). The significant oligocythaemia, anaemia, reduced packed cell volume found in active TB positive persons are all attributed to invasion of haematopoietic organs by any of the Mycobacteria tuberculosis complex (MTBC) namely: M tuberculosis, M. bovis, M africanum, M. canetti, M. microti, and M. leprae, which reduced substantially the rate of erythropoiesis. The invasion of lymphoid organs such as lymph nodes, thymus and tonsils by MTBC stimulated the synthesis of leucocytes leading to leucocytosis (p and lt;0.05). This could be an inflammatory response which prepared the victim to defend itself against any of the MTBC that invaded the lungs and might even invade other extrapulmonary organs. Thrombocythaemia in active TB is attributed to haemoptysis, since the latter occurs whenever there is a wound or a threat to tissue injury or damage. When these changes in haematological parameters are used in combination with other tests, microscopic and clinical methods, TB diagnosis and treatment could be well improved. |
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| ISSN: | 2315-9650 2502-0524 |