Adaptive Immunity to Hepatitis C Virus
The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This revie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-09-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/1/2/276/ |
| _version_ | 1818064766774542336 |
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| author | Françoise Stoll-Keller Thomas f. Baumert François Habersetzer Samira Fafi-Kremer Eric Robinet Mirjam B. Zeisel |
| author_facet | Françoise Stoll-Keller Thomas f. Baumert François Habersetzer Samira Fafi-Kremer Eric Robinet Mirjam B. Zeisel |
| author_sort | Françoise Stoll-Keller |
| collection | DOAJ |
| description | The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on different aspects of the adaptive immune responses as determinants of the different outcomes of HCV infection, clearance or persistent infection, and outlines current concepts of HCV evasion strategies. Unravelling these important mechanisms of virus-host interaction will contribute to the development of novel strategies to prevent and control HCV infection. |
| first_indexed | 2024-12-10T14:41:13Z |
| format | Article |
| id | doaj.art-60898454c41f490699fb6df683179920 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-10T14:41:13Z |
| publishDate | 2009-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-60898454c41f490699fb6df6831799202022-12-22T01:44:41ZengMDPI AGViruses1999-49152009-09-011227629710.3390/v1020276Adaptive Immunity to Hepatitis C VirusFrançoise Stoll-KellerThomas f. BaumertFrançois HabersetzerSamira Fafi-KremerEric RobinetMirjam B. ZeiselThe precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on different aspects of the adaptive immune responses as determinants of the different outcomes of HCV infection, clearance or persistent infection, and outlines current concepts of HCV evasion strategies. Unravelling these important mechanisms of virus-host interaction will contribute to the development of novel strategies to prevent and control HCV infection.http://www.mdpi.com/1999-4915/1/2/276/viral clearanceneutralizing antibodiesT cellsescapevaccine development |
| spellingShingle | Françoise Stoll-Keller Thomas f. Baumert François Habersetzer Samira Fafi-Kremer Eric Robinet Mirjam B. Zeisel Adaptive Immunity to Hepatitis C Virus Viruses viral clearance neutralizing antibodies T cells escape vaccine development |
| title | Adaptive Immunity to Hepatitis C Virus |
| title_full | Adaptive Immunity to Hepatitis C Virus |
| title_fullStr | Adaptive Immunity to Hepatitis C Virus |
| title_full_unstemmed | Adaptive Immunity to Hepatitis C Virus |
| title_short | Adaptive Immunity to Hepatitis C Virus |
| title_sort | adaptive immunity to hepatitis c virus |
| topic | viral clearance neutralizing antibodies T cells escape vaccine development |
| url | http://www.mdpi.com/1999-4915/1/2/276/ |
| work_keys_str_mv | AT francoisestollkeller adaptiveimmunitytohepatitiscvirus AT thomasfbaumert adaptiveimmunitytohepatitiscvirus AT francoishabersetzer adaptiveimmunitytohepatitiscvirus AT samirafafikremer adaptiveimmunitytohepatitiscvirus AT ericrobinet adaptiveimmunitytohepatitiscvirus AT mirjambzeisel adaptiveimmunitytohepatitiscvirus |