Impact of Regorafenib on Endothelial Transdifferentiation of Glioblastoma Stem-like Cells

Impact of Regorafenib on Endothelial Transdifferentiation of Glioblastoma Stem-like Cells

Glioblastomas (GBM) are aggressive brain tumours with a poor prognosis despite heavy therapy that combines surgical resection and radio-chemotherapy. The presence of a subpopulation of GBM stem cells (GSC) contributes to tumour aggressiveness, resistance and recurrence. Moreover, GBM are characteris...

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Bibliographic Details
Main Authors: Pauline Deshors, Florent Arnauduc, Betty Boëlle, Elizabeth Cohen-Jonathan Moyal, Monique Courtade-Saïdi, Solène M. Evrard
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
regorafenib
glioblastoma
glioblastoma stem-like cells
transdifferentiation
tumour-derived endothelial cells
ionising radiation
Online Access:https://www.mdpi.com/2072-6694/14/6/1551

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