The activation of the Sox2 RR2 pluripotency transcriptional reporter in human breast cancer cell lines is dynamic and labels cells with higher tumorigenic potential

The activation of the Sox2 RR2 pluripotency transcriptional reporter in human breast cancer cell lines is dynamic and labels cells with higher tumorigenic potential

The striking similarity displayed at the mechanistic level between tumorigenesis and the generation of induced pluripotent stem cells and the fact that genes and pathways relevant for embryonic development are reactivated during tumor progression highlights the link between pluripotency and cancer....

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Bibliographic Details
Main Authors: Juan Manuel eIglesias, Olatz eLeis Esnaola, Estibaliz ePerez Ruiz, Juan eGumuzio Barrie, Francisco eGarcia Garcia, Ariane eAduriz, Izaskun eBeloqui, Susana eHernandez Garcia, Maria Paz eLopez Mato, Joaquin eDopazo, Atanasio ePandiella, Javier eMenendez, Angel eGarcia Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Oncology
Subjects:
Stem Cells
EMT
reporter
SOX2
pluripotency
breast cancer stem cell
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00308/full

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