Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up study
Colorectal cancer is a serious cancer with high mortality. Most of the recurrence usually occurred within two years after surgery. This study was conducted in Nineveh Medical Center and Al-Jammhorri Hospital to evaluate colorectal cancer patients in a follow up study for two years. Serum carcino...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2022-04-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/791 |
| _version_ | 1797223924719681536 |
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| author | Taha HT Al-Saigh Shatha A Abdulmawjood Faris A Ahmed |
| author_facet | Taha HT Al-Saigh Shatha A Abdulmawjood Faris A Ahmed |
| author_sort | Taha HT Al-Saigh |
| collection | DOAJ |
| description |
Colorectal cancer is a serious cancer with high mortality. Most of the recurrence usually occurred within two years after surgery. This study was conducted in Nineveh Medical Center and Al-Jammhorri Hospital to evaluate colorectal cancer patients in a follow up study for
two years. Serum carcinoembryonic antigen, colonoscopy, ultrasound of the abdomen, and chest X rays were used for evaluation. One hundred and ninety-four patients with colorectal cancer were included in the study. The patients were diagnosed colorectal adenocarcinomas by histopathology and staged according to Duke’s classification. The patients were undergone surgical removal of the cancer. Chemotherapy was started to the patient after two weeks of the surgery. Blood samples were taken one week before and one week after surgery. Other blood samples were taken after chemotherapy and then every six months for two years. The blood samples were analyzed for serum carcinoembryonic antigen. The patients were also checked by colonoscopy, ultrasound for abdomen, and chest X ray every six months. Serum carcinoembryonic antigen in colorectal patients was higher than 5 ng/mL and decreased significantly after surgery but still higher than 5 ng/mL. After chemotherapy serum decreased significantly compared with that after surgery. During the two-year period serum carcinoembryonic antigen was not significantly different from that in patients after chemotherapy. Twenty-one patients died after two years of the study Serum carcinoembryonic antigen in the dead patients was much significantly higher than 5 ng/mL before surgery and decreased significantly after operation and after chemotherapy but still higher than 5 ng/mL. In conclusion, colorectal cancer is a significant disease in Iraq. The mortality rate is high due to lack of education of the community to that disease. Carcinoembryonic antigen marker is still acceptable test but should be used with other clinical assessments
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| first_indexed | 2024-04-24T13:44:57Z |
| format | Article |
| id | doaj.art-609378230fe84287b8192dcb2d8a70b4 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:44:57Z |
| publishDate | 2022-04-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-609378230fe84287b8192dcb2d8a70b42024-04-04T06:56:30ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2022-04-0121310.32947/ajps.v21i3.791Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up studyTaha HT Al-Saigh0Shatha A Abdulmawjood1Faris A Ahmed2Ninevah College of Medicine, University of Nineveh, MosulNinevah College of Medicine, University of Nineveh, MosulCollege of Pharmacy, University of Uruk, Baghdad Colorectal cancer is a serious cancer with high mortality. Most of the recurrence usually occurred within two years after surgery. This study was conducted in Nineveh Medical Center and Al-Jammhorri Hospital to evaluate colorectal cancer patients in a follow up study for two years. Serum carcinoembryonic antigen, colonoscopy, ultrasound of the abdomen, and chest X rays were used for evaluation. One hundred and ninety-four patients with colorectal cancer were included in the study. The patients were diagnosed colorectal adenocarcinomas by histopathology and staged according to Duke’s classification. The patients were undergone surgical removal of the cancer. Chemotherapy was started to the patient after two weeks of the surgery. Blood samples were taken one week before and one week after surgery. Other blood samples were taken after chemotherapy and then every six months for two years. The blood samples were analyzed for serum carcinoembryonic antigen. The patients were also checked by colonoscopy, ultrasound for abdomen, and chest X ray every six months. Serum carcinoembryonic antigen in colorectal patients was higher than 5 ng/mL and decreased significantly after surgery but still higher than 5 ng/mL. After chemotherapy serum decreased significantly compared with that after surgery. During the two-year period serum carcinoembryonic antigen was not significantly different from that in patients after chemotherapy. Twenty-one patients died after two years of the study Serum carcinoembryonic antigen in the dead patients was much significantly higher than 5 ng/mL before surgery and decreased significantly after operation and after chemotherapy but still higher than 5 ng/mL. In conclusion, colorectal cancer is a significant disease in Iraq. The mortality rate is high due to lack of education of the community to that disease. Carcinoembryonic antigen marker is still acceptable test but should be used with other clinical assessments https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/791 |
| spellingShingle | Taha HT Al-Saigh Shatha A Abdulmawjood Faris A Ahmed Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up study Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| title | Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up study |
| title_full | Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up study |
| title_fullStr | Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up study |
| title_full_unstemmed | Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up study |
| title_short | Prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients: a follow up study |
| title_sort | prognostic factor of serum carcinoembryonic antigen in colorectal cancer patients a follow up study |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/791 |
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