Cytotoxic Impact of Fluorinated Ligands in Equatorial Position of Trans-Configured Diam(m)inetetracarboxylatoplatinum(IV) Complexes

Cytotoxic Impact of Fluorinated Ligands in Equatorial Position of Trans-Configured Diam(m)inetetracarboxylatoplatinum(IV) Complexes

A series of thirty novel tetracarboxylatoplatinum(IV) complexes in <i>trans</i>-configuration featuring combinations of mixed ammine, methylamine, dimethylamine, and cyclopentylamine ligands as well as acetato/propanoato and trifluoropropanoato ligands was synthesised. The platinum(IV) c...

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Bibliographic Details
Main Authors: Yvonne Lerchbammer-Kreith, Michaela Hejl, Dominik Wenisch, Michael A. Jakupec, Mathea S. Galanski, Bernhard K. Keppler
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Inorganics
Subjects:
platinum(IV) complexes
<i>trans</i>-configuration
fluorinated ligands
lipophilicity
cytotoxicity
apoptosis
Online Access:https://www.mdpi.com/2304-6740/11/10/411

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