New onset diabetes mellitus in post-COVID-19 patients
Background: Diabetes, is known to have a bilateral relationship with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Precise mechanism of diabetes onset in COVID-19 patients remains unclear. Aim: To analyse the incidence of new onset diabetes (NODM) among COVID-19 patients, as well as...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=10;spage=5961;epage=5968;aulast=Keerthi |
| _version_ | 1811296322166194176 |
|---|---|
| author | B Y Keerthi G Sushmita Ehsan A Khan Vimala Thomas Vikram Cheryala Chirali Shah G Ravi Kumar V Haritha |
| author_facet | B Y Keerthi G Sushmita Ehsan A Khan Vimala Thomas Vikram Cheryala Chirali Shah G Ravi Kumar V Haritha |
| author_sort | B Y Keerthi |
| collection | DOAJ |
| description | Background: Diabetes, is known to have a bilateral relationship with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Precise mechanism of diabetes onset in COVID-19 patients remains unclear. Aim: To analyse the incidence of new onset diabetes (NODM) among COVID-19 patients, as well as the effect of body mass index (BMI), family history, and steroid use on the incidence of the disease. Methods: Adult, not known diabetic patients, tested positive with Rapid Antigen Test or RT-PCR admitted to a tertiary care hospital and research institute were included in the present prospective observational study. The patients who developed NODM and NOPD (New Onset Pre-diabetes) during the three months follow-up and the risk factors associated were assessed. Patients with HbA1c >6.4% were diagnosed with NODM. An HbA1c of 5.7% to 6.4% was used to characterize NOPD. Results: Out of 273 previously not known diabetic COVID-19 infected individuals, a total of 100 were studied for three months after consent. Mean age of the patients 48.31 ± 19.07 years with male predominance (67%). Among these, 58% were non-diabetics and 42% were pre-diabetics. 6 (10.3%) of the 58 non-diabetics developed NOPD, and 8 (13.8%) developed NODM. 6 (14.2%) of the 42 pre-diabetics became non-diabetic, and 16.6% (7) developed NODM. Family history of DM (P < 0.001), severity at admission (P < 0.006), diabetic ketoacidosis (P < 0.0275), and persistent symptoms were associated significantly with NODM. Those with NODM had significantly greater BMI, O2 duration, steroid duration, FBS, and PPBS (P < 0.001 for all). Nearly 67% of the patients who developed NOPD had shortness of breath as the common symptom at time of admission (P = 0.0165). Conclusion: The incidence of NODM was strongly influenced by positive family history of DM, higher BMI, steroid dosage, and its duration. Hence, patients with COVID-19 need to be under surveillance for blood glucose screening. |
| first_indexed | 2024-04-13T05:47:41Z |
| format | Article |
| id | doaj.art-60962824ac5a46b98be736dc166f9b54 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-04-13T05:47:41Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-60962824ac5a46b98be736dc166f9b542022-12-22T02:59:55ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632022-01-0111105961596810.4103/jfmpc.jfmpc_316_22New onset diabetes mellitus in post-COVID-19 patientsB Y KeerthiG SushmitaEhsan A KhanVimala ThomasVikram CheryalaChirali ShahG Ravi KumarV HarithaBackground: Diabetes, is known to have a bilateral relationship with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Precise mechanism of diabetes onset in COVID-19 patients remains unclear. Aim: To analyse the incidence of new onset diabetes (NODM) among COVID-19 patients, as well as the effect of body mass index (BMI), family history, and steroid use on the incidence of the disease. Methods: Adult, not known diabetic patients, tested positive with Rapid Antigen Test or RT-PCR admitted to a tertiary care hospital and research institute were included in the present prospective observational study. The patients who developed NODM and NOPD (New Onset Pre-diabetes) during the three months follow-up and the risk factors associated were assessed. Patients with HbA1c >6.4% were diagnosed with NODM. An HbA1c of 5.7% to 6.4% was used to characterize NOPD. Results: Out of 273 previously not known diabetic COVID-19 infected individuals, a total of 100 were studied for three months after consent. Mean age of the patients 48.31 ± 19.07 years with male predominance (67%). Among these, 58% were non-diabetics and 42% were pre-diabetics. 6 (10.3%) of the 58 non-diabetics developed NOPD, and 8 (13.8%) developed NODM. 6 (14.2%) of the 42 pre-diabetics became non-diabetic, and 16.6% (7) developed NODM. Family history of DM (P < 0.001), severity at admission (P < 0.006), diabetic ketoacidosis (P < 0.0275), and persistent symptoms were associated significantly with NODM. Those with NODM had significantly greater BMI, O2 duration, steroid duration, FBS, and PPBS (P < 0.001 for all). Nearly 67% of the patients who developed NOPD had shortness of breath as the common symptom at time of admission (P = 0.0165). Conclusion: The incidence of NODM was strongly influenced by positive family history of DM, higher BMI, steroid dosage, and its duration. Hence, patients with COVID-19 need to be under surveillance for blood glucose screening.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=10;spage=5961;epage=5968;aulast=Keerthibmifamily history of dmhba1cnodmnopdsars-cov-2steroids |
| spellingShingle | B Y Keerthi G Sushmita Ehsan A Khan Vimala Thomas Vikram Cheryala Chirali Shah G Ravi Kumar V Haritha New onset diabetes mellitus in post-COVID-19 patients Journal of Family Medicine and Primary Care bmi family history of dm hba1c nodm nopd sars-cov-2 steroids |
| title | New onset diabetes mellitus in post-COVID-19 patients |
| title_full | New onset diabetes mellitus in post-COVID-19 patients |
| title_fullStr | New onset diabetes mellitus in post-COVID-19 patients |
| title_full_unstemmed | New onset diabetes mellitus in post-COVID-19 patients |
| title_short | New onset diabetes mellitus in post-COVID-19 patients |
| title_sort | new onset diabetes mellitus in post covid 19 patients |
| topic | bmi family history of dm hba1c nodm nopd sars-cov-2 steroids |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=10;spage=5961;epage=5968;aulast=Keerthi |
| work_keys_str_mv | AT bykeerthi newonsetdiabetesmellitusinpostcovid19patients AT gsushmita newonsetdiabetesmellitusinpostcovid19patients AT ehsanakhan newonsetdiabetesmellitusinpostcovid19patients AT vimalathomas newonsetdiabetesmellitusinpostcovid19patients AT vikramcheryala newonsetdiabetesmellitusinpostcovid19patients AT chiralishah newonsetdiabetesmellitusinpostcovid19patients AT gravikumar newonsetdiabetesmellitusinpostcovid19patients AT vharitha newonsetdiabetesmellitusinpostcovid19patients |