Domperidone Inhibits <i>Clostridium botulinum</i> C2 Toxin and <i>Bordetella pertussis</i> Toxin

Domperidone Inhibits <i>Clostridium botulinum</i> C2 Toxin and <i>Bordetella pertussis</i> Toxin

<i>Bordetella pertussis</i> toxin (PT) and <i>Clostridium botulinum</i> C2 toxin are ADP-ribosylating toxins causing severe diseases in humans and animals. They share a common translocation mechanism requiring the cellular chaperones Hsp90 and Hsp70, cyclophilins, and FK506-b...

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Bibliographic Details
Main Authors: Jinfang Jia, Maria Braune-Yan, Stefanie Lietz, Mary Wahba, Arto T. Pulliainen, Holger Barth, Katharina Ernst
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Toxins
Subjects:
AB-type protein toxin
ADP-ribosylating toxin
pertussis toxin
whooping cough
C2 toxin
membrane transport
Online Access:https://www.mdpi.com/2072-6651/15/7/412

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