Rational Framework for the Design of Trp- and Arg-Rich Peptide Antibiotics Against Multidrug-Resistant Bacteria

Rational Framework for the Design of Trp- and Arg-Rich Peptide Antibiotics Against Multidrug-Resistant Bacteria

The threat of antibiotic resistance warrants the discovery of agents with novel antimicrobial mechanisms. Antimicrobial peptides (AMPs) directly disrupting bacterial membranes may overcome resistance to traditional antibiotics. AMP development for clinical use has been mostly limited to topical appl...

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Bibliographic Details
Main Authors: Wenyu Xiang, Patrice Clemenza, Jessie Klousnitzer, Jespar Chen, Weiheng Qin, Stephanie Tristram-Nagle, Yohei Doi, Y. Peter Di, Berthony Deslouches
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial peptides
antibiotic resistance
peptide antibiotics
multidrug resistance
ESKAPE pathogens
antimicrobial agents
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.889791/full

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