Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats
Spinal cord injury (SCI) is an incurable condition in which the brain is disconnected partially or completely from the periphery. Mainly, SCIs are traumatic and are due to traffic, domestic or sport accidents. To date, SCIs are incurable and, most of the time, leave the patients with a permanent los...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1827 |
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| author | Amandine Robac Pauline Neveu Alizée Hugede Elisabeth Garrido Lionel Nicol Quentin Delarue Nicolas Guérout |
| author_facet | Amandine Robac Pauline Neveu Alizée Hugede Elisabeth Garrido Lionel Nicol Quentin Delarue Nicolas Guérout |
| author_sort | Amandine Robac |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is an incurable condition in which the brain is disconnected partially or completely from the periphery. Mainly, SCIs are traumatic and are due to traffic, domestic or sport accidents. To date, SCIs are incurable and, most of the time, leave the patients with a permanent loss of sensitive and motor functions. Therefore, for several decades, researchers have tried to develop treatments to cure SCI. Among them, recently, our lab has demonstrated that, in mice, repetitive trans-spinal magnetic stimulation (rTSMS) can, after SCI, modulate the lesion scar and can induce functional locomotor recovery non-invasively. These results are promising; however, before we can translate them to humans, it is important to reproduce them in a more clinically relevant model. Indeed, SCIs do not lead to the same cellular events in mice and humans. In particular, SCIs in humans induce the formation of cystic cavities. That is why we propose here to validate the effects of rTSMS in a rat animal model in which SCI leads to the formation of cystic cavities after penetrating and contusive SCI. To do so, several techniques, including immunohistochemical, behavioral and MRI, were performed. Our results demonstrate that rTSMS, in both SCI models, modulates the lesion scar by decreasing the formation of cystic cavities and by improving axonal survival. Moreover, rTSMS, in both models, enhances functional locomotor recovery. Altogether, our study describes that rTSMS exerts positive effects after SCI in rats. This study is a further step towards the use of this treatment in humans. |
| first_indexed | 2024-03-10T04:33:41Z |
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| id | doaj.art-609e2f0e78c246ac9ad29b1eaddd7763 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:33:41Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-609e2f0e78c246ac9ad29b1eaddd77632023-11-23T03:56:12ZengMDPI AGBiomedicines2227-90592021-12-01912182710.3390/biomedicines9121827Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in RatsAmandine Robac0Pauline Neveu1Alizée Hugede2Elisabeth Garrido3Lionel Nicol4Quentin Delarue5Nicolas Guérout6EA3830 GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, UNIROUEN, 76000 Rouen, FranceEA3830 GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, UNIROUEN, 76000 Rouen, FranceEA3830 GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, UNIROUEN, 76000 Rouen, FranceEA3830 GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, UNIROUEN, 76000 Rouen, FranceInstitute for Research and Innovation in Biomedicine (IRIB), Normandy University, UNIROUEN, Inserm U1096, 76000 Rouen, FranceEA3830 GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, UNIROUEN, 76000 Rouen, FranceEA3830 GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Normandy University, UNIROUEN, 76000 Rouen, FranceSpinal cord injury (SCI) is an incurable condition in which the brain is disconnected partially or completely from the periphery. Mainly, SCIs are traumatic and are due to traffic, domestic or sport accidents. To date, SCIs are incurable and, most of the time, leave the patients with a permanent loss of sensitive and motor functions. Therefore, for several decades, researchers have tried to develop treatments to cure SCI. Among them, recently, our lab has demonstrated that, in mice, repetitive trans-spinal magnetic stimulation (rTSMS) can, after SCI, modulate the lesion scar and can induce functional locomotor recovery non-invasively. These results are promising; however, before we can translate them to humans, it is important to reproduce them in a more clinically relevant model. Indeed, SCIs do not lead to the same cellular events in mice and humans. In particular, SCIs in humans induce the formation of cystic cavities. That is why we propose here to validate the effects of rTSMS in a rat animal model in which SCI leads to the formation of cystic cavities after penetrating and contusive SCI. To do so, several techniques, including immunohistochemical, behavioral and MRI, were performed. Our results demonstrate that rTSMS, in both SCI models, modulates the lesion scar by decreasing the formation of cystic cavities and by improving axonal survival. Moreover, rTSMS, in both models, enhances functional locomotor recovery. Altogether, our study describes that rTSMS exerts positive effects after SCI in rats. This study is a further step towards the use of this treatment in humans.https://www.mdpi.com/2227-9059/9/12/1827rehabilitationspinal cord injuryglial scarmagnetic stimulationcystic cavities and functional recovery |
| spellingShingle | Amandine Robac Pauline Neveu Alizée Hugede Elisabeth Garrido Lionel Nicol Quentin Delarue Nicolas Guérout Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats Biomedicines rehabilitation spinal cord injury glial scar magnetic stimulation cystic cavities and functional recovery |
| title | Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats |
| title_full | Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats |
| title_fullStr | Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats |
| title_full_unstemmed | Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats |
| title_short | Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats |
| title_sort | repetitive trans spinal magnetic stimulation improves functional recovery and tissue repair in contusive and penetrating spinal cord injury models in rats |
| topic | rehabilitation spinal cord injury glial scar magnetic stimulation cystic cavities and functional recovery |
| url | https://www.mdpi.com/2227-9059/9/12/1827 |
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