Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish
Relapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis of patients; however, prognostic markers or therapeutic targets for ALL remain unknown. In the present study, using databases such as TARGET, GSE60926 and GSE28460, we determined that <i>KIF2C</i> and...
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3127 |
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| author | Chang-Kyu Oh Ji Wan Kang Yoonsung Lee Kyungjae Myung Mihyang Ha Junho Kang Eun Jung Kwon Youngjoo Kim Sae-Ock Oh Hye Jin Heo Shin Kim Yun Hak Kim |
| author_facet | Chang-Kyu Oh Ji Wan Kang Yoonsung Lee Kyungjae Myung Mihyang Ha Junho Kang Eun Jung Kwon Youngjoo Kim Sae-Ock Oh Hye Jin Heo Shin Kim Yun Hak Kim |
| author_sort | Chang-Kyu Oh |
| collection | DOAJ |
| description | Relapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis of patients; however, prognostic markers or therapeutic targets for ALL remain unknown. In the present study, using databases such as TARGET, GSE60926 and GSE28460, we determined that <i>KIF2C</i> and its binding partner, <i>KIF18B</i> are overexpressed in patients with relapsed ALL compared to that in patients diagnosed with ALL for the first time. As 50% of the residues are exactly the same and the signature domain of <i>KIF2C</i> is highly conserved between human and zebrafish, we used zebrafish embryos as a model to investigate the function of <i>kif2c</i> in vivo. We determined that <i>kif2c</i> is necessary for lymphopoiesis in zebrafish embryos. Additionally, we observed that <i>kif2c</i> is not related to differentiation of HSCs; however, it is important for the maintenance of HSCs as it provides survival signals to HSCs. These results imply that the ALL relapse-related gene <i>KIF2C</i> is linked to the survival of HSCs. In conclusion, we suggest that <i>KIF2C</i> can serve as a novel therapeutic target for relapsed ALL. |
| first_indexed | 2024-03-10T20:10:26Z |
| format | Article |
| id | doaj.art-609edcf84a8d4815aab28dd26dfdb423 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:10:26Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-609edcf84a8d4815aab28dd26dfdb4232023-11-19T22:59:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01219312710.3390/ijms21093127Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in ZebrafishChang-Kyu Oh0Ji Wan Kang1Yoonsung Lee2Kyungjae Myung3Mihyang Ha4Junho Kang5Eun Jung Kwon6Youngjoo Kim7Sae-Ock Oh8Hye Jin Heo9Shin Kim10Yun Hak Kim11Center for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, KoreaInterdisciplinary Program of Genomic Science, Pusan National University, Yangsan 50612, KoreaCenter for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, KoreaCenter for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, KoreaInterdisciplinary Program of Genomic Science, Pusan National University, Yangsan 50612, KoreaInterdisciplinary Program of Genomic Science, Pusan National University, Yangsan 50612, KoreaInterdisciplinary Program of Genomic Science, Pusan National University, Yangsan 50612, KoreaInterdisciplinary Program of Genomic Science, Pusan National University, Yangsan 50612, KoreaDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, KoreaDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, KoreaDepartment of Immunology, School of Medicine, Keimyung University, Dalseo-gu, Daegu 42601, KoreaDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, KoreaRelapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis of patients; however, prognostic markers or therapeutic targets for ALL remain unknown. In the present study, using databases such as TARGET, GSE60926 and GSE28460, we determined that <i>KIF2C</i> and its binding partner, <i>KIF18B</i> are overexpressed in patients with relapsed ALL compared to that in patients diagnosed with ALL for the first time. As 50% of the residues are exactly the same and the signature domain of <i>KIF2C</i> is highly conserved between human and zebrafish, we used zebrafish embryos as a model to investigate the function of <i>kif2c</i> in vivo. We determined that <i>kif2c</i> is necessary for lymphopoiesis in zebrafish embryos. Additionally, we observed that <i>kif2c</i> is not related to differentiation of HSCs; however, it is important for the maintenance of HSCs as it provides survival signals to HSCs. These results imply that the ALL relapse-related gene <i>KIF2C</i> is linked to the survival of HSCs. In conclusion, we suggest that <i>KIF2C</i> can serve as a novel therapeutic target for relapsed ALL.https://www.mdpi.com/1422-0067/21/9/3127KIF2CTARGETGEOALLzebrafishhematopoiesis |
| spellingShingle | Chang-Kyu Oh Ji Wan Kang Yoonsung Lee Kyungjae Myung Mihyang Ha Junho Kang Eun Jung Kwon Youngjoo Kim Sae-Ock Oh Hye Jin Heo Shin Kim Yun Hak Kim Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish International Journal of Molecular Sciences KIF2C TARGET GEO ALL zebrafish hematopoiesis |
| title | Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish |
| title_full | Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish |
| title_fullStr | Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish |
| title_full_unstemmed | Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish |
| title_short | Role of <i>kif2c</i>, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish |
| title_sort | role of i kif2c i a gene related to all relapse in embryonic hematopoiesis in zebrafish |
| topic | KIF2C TARGET GEO ALL zebrafish hematopoiesis |
| url | https://www.mdpi.com/1422-0067/21/9/3127 |
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