Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia)
The presence and cell localization of TrkB, the main receptor for the neurotrophins (NTs), was investigated immunohistochemically in the small intestine of adult pigeons, with special reference to the enteric nervous system (ENS). Several neuronal (neurofilament proteins and PGP 9.5) and glial cell...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2009-06-01
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| Series: | European Journal of Histochemistry |
| Online Access: | https://www.ejh.it/index.php/ejh/article/view/910 |
| _version_ | 1818664141144981504 |
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| author | A Germanà MB Levanti DF Monjil E Ciriaco |
| author_facet | A Germanà MB Levanti DF Monjil E Ciriaco |
| author_sort | A Germanà |
| collection | DOAJ |
| description | The presence and cell localization of TrkB, the main receptor for the neurotrophins (NTs), was investigated immunohistochemically in the small intestine of adult pigeons, with special reference to the enteric nervous system (ENS). Several neuronal (neurofilament proteins and PGP 9.5) and glial cell (S100 protein) markers were studied in parallel. TrkB immunoreactivity (TrkB-IR) was found to be restricted to immunohistochemically-identified glial cells present in the enteric plexuses, and to Schwann cells forming the perivascular plexus. Also, TrkB-IR was detected in enterochromaffin cells and in unidentified dendritic cells within the gut-associated lymphoid tissue. The present results demonstrate that as for mammals, TrkB in the ENS is restricted to the glial cells. The possible function of the TrkB ligands, however, remains to be established. |
| first_indexed | 2024-12-17T05:28:01Z |
| format | Article |
| id | doaj.art-609f8d15a1be4ce182d4ce52960af45e |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-17T05:28:01Z |
| publishDate | 2009-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-609f8d15a1be4ce182d4ce52960af45e2022-12-21T22:01:48ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062009-06-0148410.4081/910628Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia)A Germanà MB LevantiDF MonjilE CiriacoThe presence and cell localization of TrkB, the main receptor for the neurotrophins (NTs), was investigated immunohistochemically in the small intestine of adult pigeons, with special reference to the enteric nervous system (ENS). Several neuronal (neurofilament proteins and PGP 9.5) and glial cell (S100 protein) markers were studied in parallel. TrkB immunoreactivity (TrkB-IR) was found to be restricted to immunohistochemically-identified glial cells present in the enteric plexuses, and to Schwann cells forming the perivascular plexus. Also, TrkB-IR was detected in enterochromaffin cells and in unidentified dendritic cells within the gut-associated lymphoid tissue. The present results demonstrate that as for mammals, TrkB in the ENS is restricted to the glial cells. The possible function of the TrkB ligands, however, remains to be established.https://www.ejh.it/index.php/ejh/article/view/910 |
| spellingShingle | A Germanà MB Levanti DF Monjil E Ciriaco Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia) European Journal of Histochemistry |
| title | Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia) |
| title_full | Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia) |
| title_fullStr | Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia) |
| title_full_unstemmed | Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia) |
| title_short | Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia) |
| title_sort | immunohistochemical detection of tyrosine kinase b trkb in the enteric nervous system of the small intestine in pigeon columba livia |
| url | https://www.ejh.it/index.php/ejh/article/view/910 |
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