Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling

Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling

Keloid and hypertrophic scars are skin fibrosis-associated disorders that exhibit an uncontrollable proliferation of fibroblasts and their subsequent contribution to the excessive accumulation of extracellular matrix (ECM) in the dermis. In this study, to elucidate the underlying mechanisms, we inve...

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Bibliographic Details
Main Authors: Hyunbum Kim, Laurensia Danis Anggradita, Sun-Jae Lee, Sung Sik Hur, Joonsuk Bae, Nathaniel Suk-Yeon Hwang, Seung Min Nam, Yongsung Hwang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
keloid scar
hypertrophic scar
dermal fibroblast
epidermal growth factor
ECM remodeling
traction force
Online Access:https://www.mdpi.com/1422-0067/22/4/2198

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