SDH, a novel diarylheptane compound, is a potential treatment for inflammatory bowel disease by restoring epithelial barrier function

SDH, a novel diarylheptane compound, is a potential treatment for inflammatory bowel disease by restoring epithelial barrier function

Background: The global prevalence of inflammatory bowel disease (IBD) is increasing, and mucosal healing is the preferred treatment target of IBD. Sodium (aS,9 R)− 3-hydroxy-16,17-dimethoxy-15-oxidotricyclo[12.3.1.12,6]nonadeca-1(18),2,4,6(19),14,16-hexene-9-yl sulfate hydrate (SDH) is a novel diary...

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Bibliographic Details
Main Authors: Fei Yang, Xiaoqiang Zhu, Liu Li, Yanping Wang, Qing Xie, Yu Cao, Yunhui Yu, Minjie Zhang, Dong Li, Ling Li, Zhongtian Liu, Biyan Zhang, Zijun Chen, Shiping Deng, Yunsen Li
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Inflammatory bowel disease
Epithelial barrier function
Tight junction proteins
Safety pharmacology
Nonclinical toxicology
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222004693

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http://www.sciencedirect.com/science/article/pii/S0753332222004693

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