How mouse macrophages sense what is going on
Macrophages are central to both innate and adaptive immunity. With few exceptions, macrophages are the first cells that sense trouble and respond to disturbances in almost all tissues and organs. They sense their environment, inhibit or kill pathogens, take up apoptotic and necrotic cells, heal tiss...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00204/full |
| _version_ | 1818967523769450496 |
|---|---|
| author | Klaus eLey Akula Bala ePramod Michael eCroft Kodi eRavichandran Jenny eTing |
| author_facet | Klaus eLey Akula Bala ePramod Michael eCroft Kodi eRavichandran Jenny eTing |
| author_sort | Klaus eLey |
| collection | DOAJ |
| description | Macrophages are central to both innate and adaptive immunity. With few exceptions, macrophages are the first cells that sense trouble and respond to disturbances in almost all tissues and organs. They sense their environment, inhibit or kill pathogens, take up apoptotic and necrotic cells, heal tissue damage, and present antigens to T cells. Although the origins [yolk sac versus monocyte-derived] and phenotypes [functions, gene expression profiles, surface markers] of macrophages vary between tissues, they have many receptors in common that are specific to one or a few molecular species. Here, we review the expression and function of almost 200 key macrophage receptors that help the macrophages sense what is going on, including pathogen-derived molecules, the state of the surrounding tissue cells, apoptotic and necrotic cell death, antibodies and immune complexes, altered self molecules, extracellular matrix components, and cytokines including chemokines. |
| first_indexed | 2024-12-20T13:50:09Z |
| format | Article |
| id | doaj.art-60a3fa280fd1497ca12c1c6b0b2c24ef |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T13:50:09Z |
| publishDate | 2016-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-60a3fa280fd1497ca12c1c6b0b2c24ef2022-12-21T19:38:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-06-01710.3389/fimmu.2016.00204196570How mouse macrophages sense what is going onKlaus eLey0Akula Bala ePramod1Michael eCroft2Kodi eRavichandran3Jenny eTing4La Jolla Institute for Allergy & ImmunologyLa Jolla Institute for Allergy & ImmunologyLa Jolla Institute for Allergy & ImmunologyUniversity of VirginiaUNCMacrophages are central to both innate and adaptive immunity. With few exceptions, macrophages are the first cells that sense trouble and respond to disturbances in almost all tissues and organs. They sense their environment, inhibit or kill pathogens, take up apoptotic and necrotic cells, heal tissue damage, and present antigens to T cells. Although the origins [yolk sac versus monocyte-derived] and phenotypes [functions, gene expression profiles, surface markers] of macrophages vary between tissues, they have many receptors in common that are specific to one or a few molecular species. Here, we review the expression and function of almost 200 key macrophage receptors that help the macrophages sense what is going on, including pathogen-derived molecules, the state of the surrounding tissue cells, apoptotic and necrotic cell death, antibodies and immune complexes, altered self molecules, extracellular matrix components, and cytokines including chemokines.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00204/fullChemokinesIntegrinsMacrophage ActivationMacrophagesMacrophages, AlveolarMacrophages, Peritoneal |
| spellingShingle | Klaus eLey Akula Bala ePramod Michael eCroft Kodi eRavichandran Jenny eTing How mouse macrophages sense what is going on Frontiers in Immunology Chemokines Integrins Macrophage Activation Macrophages Macrophages, Alveolar Macrophages, Peritoneal |
| title | How mouse macrophages sense what is going on |
| title_full | How mouse macrophages sense what is going on |
| title_fullStr | How mouse macrophages sense what is going on |
| title_full_unstemmed | How mouse macrophages sense what is going on |
| title_short | How mouse macrophages sense what is going on |
| title_sort | how mouse macrophages sense what is going on |
| topic | Chemokines Integrins Macrophage Activation Macrophages Macrophages, Alveolar Macrophages, Peritoneal |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00204/full |
| work_keys_str_mv | AT klauseley howmousemacrophagessensewhatisgoingon AT akulabalaepramod howmousemacrophagessensewhatisgoingon AT michaelecroft howmousemacrophagessensewhatisgoingon AT kodieravichandran howmousemacrophagessensewhatisgoingon AT jennyeting howmousemacrophagessensewhatisgoingon |