Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca<sup>2+</sup> Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins

Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca<sup>2+</sup> Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins

The trafficking of transient receptor potential (TRP) channels to the plasma membrane and the release of calcitonin gene-related peptide (CGRP) from trigeminal ganglion neurons (TGNs) are implicated in some aspects of chronic migraines. These exocytotic processes are inhibited by cleavage of SNAREs...

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Bibliographic Details
Main Authors: Mariia Belinskaia, Jiafu Wang, Seshu Kumar Kaza, Caren Antoniazzi, Tomas Zurawski, J. Oliver Dolly, Gary W. Lawrence
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
AITC
botulinum neurotoxins
calcitonin gene-related peptide
trigeminal ganglion neurons
nerve growth factor
SNAP-25
Online Access:https://www.mdpi.com/1422-0067/24/2/1338

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