NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITRO
This research aimed to make nanoparticles from Allium cepa. L extract that can inhibit Bcl-2 protein expression in MCF-7 cells in vitro. The particles were broken down to nano with the addition of NaTPP dissolved in distilled water and chitosan dissolved in 1% acetic acid. The particle size based on...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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iVolga Press
2019-06-01
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| Series: | Russian Journal of Agricultural and Socio-Economic Sciences |
| Subjects: | |
| Online Access: | https://rjoas.com/issue-2019-06/article_07.pdf |
| _version_ | 1797717257370992640 |
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| author | Jayanti S. Suseno D.N. Suseno D.A.N. |
| author_facet | Jayanti S. Suseno D.N. Suseno D.A.N. |
| author_sort | Jayanti S. |
| collection | DOAJ |
| description | This research aimed to make nanoparticles from Allium cepa. L extract that can inhibit Bcl-2 protein expression in MCF-7 cells in vitro. The particles were broken down to nano with the addition of NaTPP dissolved in distilled water and chitosan dissolved in 1% acetic acid. The particle size based on the SEM and PSA tests had an average size of 336 nm. Nanoparticles from Allium cepa. L extract based on the KLT test contained flavonoids, saponins, and tannins. MCF-7 cells were treated with doses of 40 μg/ml, 80 ug/ml, 160 ug/ml, and 320 ug/ml. The results showed that nanoparticles from Allium cepa. L extract had cytotoxicity in MCF-7 cells with the IC50 value of 235 μg/ml and proved to inhibit Bcl-2 protein expression. |
| first_indexed | 2024-03-12T08:33:47Z |
| format | Article |
| id | doaj.art-60a43d6c3c0d44be919e435cd7dbaae7 |
| institution | Directory Open Access Journal |
| issn | 2226-1184 |
| language | English |
| last_indexed | 2024-03-12T08:33:47Z |
| publishDate | 2019-06-01 |
| publisher | iVolga Press |
| record_format | Article |
| series | Russian Journal of Agricultural and Socio-Economic Sciences |
| spelling | doaj.art-60a43d6c3c0d44be919e435cd7dbaae72023-09-02T17:26:14ZengiVolga PressRussian Journal of Agricultural and Socio-Economic Sciences2226-11842019-06-01906455010.18551/rjoas.2019-06.07NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITROJayanti S.0Suseno D.N.1Suseno D.A.N.2Marine Fisheries PolytechnicMarine Fisheries PolytechnicMarine Fisheries PolytechnicThis research aimed to make nanoparticles from Allium cepa. L extract that can inhibit Bcl-2 protein expression in MCF-7 cells in vitro. The particles were broken down to nano with the addition of NaTPP dissolved in distilled water and chitosan dissolved in 1% acetic acid. The particle size based on the SEM and PSA tests had an average size of 336 nm. Nanoparticles from Allium cepa. L extract based on the KLT test contained flavonoids, saponins, and tannins. MCF-7 cells were treated with doses of 40 μg/ml, 80 ug/ml, 160 ug/ml, and 320 ug/ml. The results showed that nanoparticles from Allium cepa. L extract had cytotoxicity in MCF-7 cells with the IC50 value of 235 μg/ml and proved to inhibit Bcl-2 protein expression.https://rjoas.com/issue-2019-06/article_07.pdfAllium cepa Lnanoparticles extractBcl-2MCF-7 |
| spellingShingle | Jayanti S. Suseno D.N. Suseno D.A.N. NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITRO Russian Journal of Agricultural and Socio-Economic Sciences Allium cepa L nanoparticles extract Bcl-2 MCF-7 |
| title | NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITRO |
| title_full | NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITRO |
| title_fullStr | NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITRO |
| title_full_unstemmed | NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITRO |
| title_short | NANOPARTICLES FROM ONION (ALLIUM CEPA.L) EXTRACT SUPPRESS BCL-2 EXPRESSION IN MCF-7 CELLS IN VITRO |
| title_sort | nanoparticles from onion allium cepa l extract suppress bcl 2 expression in mcf 7 cells in vitro |
| topic | Allium cepa L nanoparticles extract Bcl-2 MCF-7 |
| url | https://rjoas.com/issue-2019-06/article_07.pdf |
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