Melatonin Can Modulate the Effect of Navitoclax (ABT-737) in HL-60 Cells

Melatonin Can Modulate the Effect of Navitoclax (ABT-737) in HL-60 Cells

Melatonin (<i>N</i>-acetyl-5-methoxytryptamine MEL) is an indolamine that has antioxidant, anti-inflammatory and anti-tumor properties. Moreover, MEL is capable of exhibiting both anti-apoptotic and pro-apoptotic effects. In the normal cells, MEL possesses antioxidant property and has an...

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Bibliographic Details
Main Authors: Alexey Lomovsky, Yulia Baburina, Irina Odinokova, Margarita Kobyakova, Yana Evstratova, Linda Sotnikova, Roman Krestinin, Olga Krestinina
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
acute promyelocytic leukemia
HL-60 cells
melatonin
navitoclax (ABT-737)
permeability transition pore
apoptosis
Online Access:https://www.mdpi.com/2076-3921/9/11/1143

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