Anti-Diabetic Activity of 2,3,6-Tribromo-4,5-Dihydroxybenzyl Derivatives from Symphyocladia latiuscula through PTP1B Downregulation and α-Glucosidase Inhibition

Anti-Diabetic Activity of 2,3,6-Tribromo-4,5-Dihydroxybenzyl Derivatives from Symphyocladia latiuscula through PTP1B Downregulation and α-Glucosidase Inhibition

The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine...

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Bibliographic Details
Main Authors: Pradeep Paudel, Su Hui Seong, Hye Jin Park, Hyun Ah Jung, Jae Sue Choi
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Marine Drugs
Subjects:
Symphyocladia latiuscula
bromophenols
PTP1B
insulin-resistant HepG2
diabetes
Online Access:http://www.mdpi.com/1660-3397/17/3/166

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