Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control Study
Sepsis is a significant health problem with an estimated 750,000 new cases in the USA annually. It is also the third leading cause of death in developed countries, equaling the number of fatalities from acute myocardial infarction. The high sepsis-related mortalities mean there is an urgent need to...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2012-06-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/21202.pdf&manuscript_id=21202 |
| _version_ | 1819111229958914048 |
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| author | Amin Niayesh Farnaz Saedi Mehrdad Hajilooi Seyyed Hamid Hashemi Mojgan Mamani Mohammad Fallah |
| author_facet | Amin Niayesh Farnaz Saedi Mehrdad Hajilooi Seyyed Hamid Hashemi Mojgan Mamani Mohammad Fallah |
| author_sort | Amin Niayesh |
| collection | DOAJ |
| description | Sepsis is a significant health problem with an estimated 750,000 new cases in the USA annually. It is also the third leading cause of death in developed countries, equaling the number of fatalities from acute myocardial infarction. The high sepsis-related mortalities mean there is an urgent need to improve the diagnosis and management of sepsis patients. The aim of this study was the evaluation of fibronectin and C-reactive protein (CRP) plasma levels in patients with sepsis and other infectious diseases without sepsis. In a case-control study, 90 patients with sepsis and 90 patients with other infectious diseases without sepsis were studied. Serum levels of fibronectin and CRP were measured. The data were analyzed by SPSS version 15. The mean levels of fibronectin in the cases and controls were 288.97±89.10 mg/l and 341.24±110.53 mg/l respectively (P=0.001). The mean levels of CRP in the cases and controls were 89.42±54.05 µg/ml and 27.42±25.89 µg/ml respectively (P<0.001). Concerning the source of infection, the mean CRP levels were significantly higher in septic patients with urinary tract infection, pneumonia, and soft tissue infection (P<0.001). Decreased levels of fibronectin and increased levels of CRP may be considered as reliable diagnostic markers for sepsis. Also, CRP could be a better predictive factor for sepsis than fibronectin. |
| first_indexed | 2024-12-22T03:54:18Z |
| format | Article |
| id | doaj.art-60a6645fb21f4347ae41587525a060ba |
| institution | Directory Open Access Journal |
| issn | 0044-6025 0173-5969 |
| language | English |
| last_indexed | 2024-12-22T03:54:18Z |
| publishDate | 2012-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-60a6645fb21f4347ae41587525a060ba2022-12-21T18:39:55ZengTehran University of Medical SciencesActa Medica Iranica0044-60250173-59692012-06-01506404410Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control StudyAmin NiayeshFarnaz SaediMehrdad HajilooiSeyyed Hamid HashemiMojgan MamaniMohammad FallahSepsis is a significant health problem with an estimated 750,000 new cases in the USA annually. It is also the third leading cause of death in developed countries, equaling the number of fatalities from acute myocardial infarction. The high sepsis-related mortalities mean there is an urgent need to improve the diagnosis and management of sepsis patients. The aim of this study was the evaluation of fibronectin and C-reactive protein (CRP) plasma levels in patients with sepsis and other infectious diseases without sepsis. In a case-control study, 90 patients with sepsis and 90 patients with other infectious diseases without sepsis were studied. Serum levels of fibronectin and CRP were measured. The data were analyzed by SPSS version 15. The mean levels of fibronectin in the cases and controls were 288.97±89.10 mg/l and 341.24±110.53 mg/l respectively (P=0.001). The mean levels of CRP in the cases and controls were 89.42±54.05 µg/ml and 27.42±25.89 µg/ml respectively (P<0.001). Concerning the source of infection, the mean CRP levels were significantly higher in septic patients with urinary tract infection, pneumonia, and soft tissue infection (P<0.001). Decreased levels of fibronectin and increased levels of CRP may be considered as reliable diagnostic markers for sepsis. Also, CRP could be a better predictive factor for sepsis than fibronectin.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/21202.pdf&manuscript_id=21202C-Rreactive ProteinFibronectinSepsis |
| spellingShingle | Amin Niayesh Farnaz Saedi Mehrdad Hajilooi Seyyed Hamid Hashemi Mojgan Mamani Mohammad Fallah Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control Study Acta Medica Iranica C-Rreactive Protein Fibronectin Sepsis |
| title | Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control Study |
| title_full | Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control Study |
| title_fullStr | Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control Study |
| title_full_unstemmed | Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control Study |
| title_short | Evaluation of Fibronectin and C-Reactive Protein Levels in Patients with Sepsis: A Case-Control Study |
| title_sort | evaluation of fibronectin and c reactive protein levels in patients with sepsis a case control study |
| topic | C-Rreactive Protein Fibronectin Sepsis |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/21202.pdf&manuscript_id=21202 |
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