Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study.
Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary album...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5889187?pdf=render |
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| author | Fumi Kishi Kojiro Nagai Norimichi Takamatsu Tatsuya Tominaga Masanori Tamaki Eriko Shibata Taichi Murakami Seiji Kishi Hideharu Abe Yasuhiko Koezuka Naoto Minagawa Go Ichien Toshio Doi |
| author_facet | Fumi Kishi Kojiro Nagai Norimichi Takamatsu Tatsuya Tominaga Masanori Tamaki Eriko Shibata Taichi Murakami Seiji Kishi Hideharu Abe Yasuhiko Koezuka Naoto Minagawa Go Ichien Toshio Doi |
| author_sort | Fumi Kishi |
| collection | DOAJ |
| description | Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted. The decline in estimated glomerular filtration rate (eGFR) was calculated. In participants with eGFR ≥80 mL/min, abnormal U-Col4 excretion was indicated as a significant independent risk factor for 10% eGFR change per year, which is one of the prognostic factors for the development of end-stage kidney disease. Moreover, in contrast to urinary albumin excretion, U-Col4 excretion was not related to age or kidney function, suggesting that some individuals with abnormal U-Col4 excretion can have an independent hidden risk for the development of kidney dysfunction. In conclusion, it is important to measure U-Col4 excretion in the general population without diabetes to determine changes in renal features in every individual and help detect future complications such as diabetic kidney disease. If U-Col4 excretion is abnormal, kidney manifestation should be carefully followed up, even if the kidney function and urinalysis findings are normal. |
| first_indexed | 2024-12-13T08:34:50Z |
| format | Article |
| id | doaj.art-60a76a0b96d14f6ea574fb361c145b71 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T08:34:50Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-60a76a0b96d14f6ea574fb361c145b712022-12-21T23:53:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019552310.1371/journal.pone.0195523Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study.Fumi KishiKojiro NagaiNorimichi TakamatsuTatsuya TominagaMasanori TamakiEriko ShibataTaichi MurakamiSeiji KishiHideharu AbeYasuhiko KoezukaNaoto MinagawaGo IchienToshio DoiUrinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted. The decline in estimated glomerular filtration rate (eGFR) was calculated. In participants with eGFR ≥80 mL/min, abnormal U-Col4 excretion was indicated as a significant independent risk factor for 10% eGFR change per year, which is one of the prognostic factors for the development of end-stage kidney disease. Moreover, in contrast to urinary albumin excretion, U-Col4 excretion was not related to age or kidney function, suggesting that some individuals with abnormal U-Col4 excretion can have an independent hidden risk for the development of kidney dysfunction. In conclusion, it is important to measure U-Col4 excretion in the general population without diabetes to determine changes in renal features in every individual and help detect future complications such as diabetic kidney disease. If U-Col4 excretion is abnormal, kidney manifestation should be carefully followed up, even if the kidney function and urinalysis findings are normal.http://europepmc.org/articles/PMC5889187?pdf=render |
| spellingShingle | Fumi Kishi Kojiro Nagai Norimichi Takamatsu Tatsuya Tominaga Masanori Tamaki Eriko Shibata Taichi Murakami Seiji Kishi Hideharu Abe Yasuhiko Koezuka Naoto Minagawa Go Ichien Toshio Doi Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study. PLoS ONE |
| title | Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study. |
| title_full | Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study. |
| title_fullStr | Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study. |
| title_full_unstemmed | Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study. |
| title_short | Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study. |
| title_sort | urinary type iv collagen excretion is involved in the decline in estimated glomerular filtration rate in the japanese general population without diabetes a 5 year observational study |
| url | http://europepmc.org/articles/PMC5889187?pdf=render |
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