Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits
Both cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are considered to be reliable biomarkers with sufficient sensitivity and specificity for cardiac injury in the majority of laboratory animals. The aim of our study was to compare the diagnostic performance of cTnT and cTnI in three groups...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2003-01-01
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| Series: | Acta Medica |
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| Online Access: | https://actamedica.lfhk.cuni.cz/46/4/0171/ |
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| author | Michaela Adamcová Martin Štěrba Ivona Klimtová Tomáš Šimůnek Radomír Hrdina Vladimír Geršl Přemysl Poňka |
| author_facet | Michaela Adamcová Martin Štěrba Ivona Klimtová Tomáš Šimůnek Radomír Hrdina Vladimír Geršl Přemysl Poňka |
| author_sort | Michaela Adamcová |
| collection | DOAJ |
| description | Both cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are considered to be reliable biomarkers with sufficient sensitivity and specificity for cardiac injury in the majority of laboratory animals. The aim of our study was to compare the diagnostic performance of cTnT and cTnI in three groups of rabbits: 1) control (saline 1 ml/kg i.v.); 2) Salicylaldehyd Isonicotinoyl Hydrazone – SIH (50 mg/kg, once weekly, i.p.; partially dissolved in 10 % Cremophor solution); 3) 10 % Cremophor solution in water (2 ml/kg i.v.). The drugs were given once a week, 10 administrations. The concentration of cTnT was measured using Elecsys Troponin T STAT Immunoassay (Roche). The concentration of cTnI was measured using AxSYM Troponin I (Abbott). The linear regression model was applied to see if there is a dependence between cTnT and cTnI. The coefficient of determination was not acceptable in all groups. The highest value of R2 was found in the control group (R2 = 0.424). We may conclude that in rabbits meaningful dependence between cTnT and cTnI was not found. According to our long-term experiences cTnT seems to be more suitable cardiomarker in rabbits in comparison with cTnI where the data are characterized by the large scatter. |
| first_indexed | 2024-12-10T08:41:37Z |
| format | Article |
| id | doaj.art-60abc12410fc4255a2de72aabe65f890 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-10T08:41:37Z |
| publishDate | 2003-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-60abc12410fc4255a2de72aabe65f8902022-12-22T01:55:50ZengKarolinum PressActa Medica1211-42861805-96942003-01-0146417117410.14712/18059694.2019.28Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in RabbitsMichaela Adamcová0Martin Štěrba1Ivona Klimtová2Tomáš Šimůnek3Radomír Hrdina4Vladimír Geršl5Přemysl Poňka6Charles University in Prague, Faculty of Medicine in Hradec Králové, Department of Physiology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Pharmacology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Pharmacology, Hradec Králové, Czech RepublicMcGill University, Department of Physiology and Medicine, Montréal, Québec, CanadaBoth cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are considered to be reliable biomarkers with sufficient sensitivity and specificity for cardiac injury in the majority of laboratory animals. The aim of our study was to compare the diagnostic performance of cTnT and cTnI in three groups of rabbits: 1) control (saline 1 ml/kg i.v.); 2) Salicylaldehyd Isonicotinoyl Hydrazone – SIH (50 mg/kg, once weekly, i.p.; partially dissolved in 10 % Cremophor solution); 3) 10 % Cremophor solution in water (2 ml/kg i.v.). The drugs were given once a week, 10 administrations. The concentration of cTnT was measured using Elecsys Troponin T STAT Immunoassay (Roche). The concentration of cTnI was measured using AxSYM Troponin I (Abbott). The linear regression model was applied to see if there is a dependence between cTnT and cTnI. The coefficient of determination was not acceptable in all groups. The highest value of R2 was found in the control group (R2 = 0.424). We may conclude that in rabbits meaningful dependence between cTnT and cTnI was not found. According to our long-term experiences cTnT seems to be more suitable cardiomarker in rabbits in comparison with cTnI where the data are characterized by the large scatter.https://actamedica.lfhk.cuni.cz/46/4/0171/Salicylaldehyd Isonicotinoyl Hydrazone (SIH)Iron chelatorTroponinRabbitBiochemical marker |
| spellingShingle | Michaela Adamcová Martin Štěrba Ivona Klimtová Tomáš Šimůnek Radomír Hrdina Vladimír Geršl Přemysl Poňka Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits Acta Medica Salicylaldehyd Isonicotinoyl Hydrazone (SIH) Iron chelator Troponin Rabbit Biochemical marker |
| title | Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits |
| title_full | Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits |
| title_fullStr | Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits |
| title_full_unstemmed | Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits |
| title_short | Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits |
| title_sort | cardiac troponins following repeated administration of an iron chelator salicylaldehyd isonicotinoyl hydrazone sih in rabbits |
| topic | Salicylaldehyd Isonicotinoyl Hydrazone (SIH) Iron chelator Troponin Rabbit Biochemical marker |
| url | https://actamedica.lfhk.cuni.cz/46/4/0171/ |
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