Cardiorespiratory fitness and response to exercise treatment in depression
BackgroundExercise improves cardiorespiratory fitness (CRF) and reduces depressive symptoms in people with depression. It is unclear if changes in CRF are a predictor of the antidepressant effect of exercise in people with depression.AimsTo investigate whether an increase in CRF is a predictor of de...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2018-09-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472418000455/type/journal_article |
| _version_ | 1811157091974381568 |
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| author | Md Shafiqur Rahman Björg Helgadóttir Mats Hallgren Yvonne Forsell Brendon Stubbs Davy Vancampfort Örjan Ekblom |
| author_facet | Md Shafiqur Rahman Björg Helgadóttir Mats Hallgren Yvonne Forsell Brendon Stubbs Davy Vancampfort Örjan Ekblom |
| author_sort | Md Shafiqur Rahman |
| collection | DOAJ |
| description | BackgroundExercise improves cardiorespiratory fitness (CRF) and reduces depressive symptoms in people with depression. It is unclear if changes in CRF are a predictor of the antidepressant effect of exercise in people with depression.AimsTo investigate whether an increase in CRF is a predictor of depression severity reduction after 12 weeks of exercise (trial registration: DRKS study ID, DRKS00008745).MethodThe present study includes participants who took part in vigorous (n = 33), moderate (n = 38) and light (n = 39) intensity exercise and had CRF information (as predicted maximal oxygen uptake, V̇O2max) collected before and after the intervention. Depression severity was measured with the Montgomery–Åsberg Depression Rating Scale (MADRS). V̇O2max (L/min) was assessed with the Åstrand–Rhyming submaximal cycle ergometry test. The main analysis was conducted pooling all exercise intensity groups together.ResultsAll exercise intensities improved V̇O2max in people with depression. Regardless of frequency and intensity of exercise, an increase in post-treatment V̇O2max was significantly associated with reduced depression severity at follow-up (B = −3.52, 95% CI −6.08 to −0.96); adjusting for intensity of exercise, age and body mass index made the association stronger (B = −3.89, 95% CI −6.53 to −1.26). Similarly, increased V̇O2max was associated with higher odds (odds ratio = 3.73, 95% CI 1.22–11.43) of exercise treatment response (≥50% reduction in MADRS score) at follow-up.ConclusionsOur data suggest that improvements in V̇O2max predict a greater reduction in depression severity among individuals who were clinically depressed. This finding indicates that improvements in V̇O2max may be a marker for the underpinning biological pathways for the antidepressant effect of exercise.Declaration of interestNone. |
| first_indexed | 2024-04-10T05:00:15Z |
| format | Article |
| id | doaj.art-60ad63bc9e19421e8c6617de75a12b0d |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:00:15Z |
| publishDate | 2018-09-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-60ad63bc9e19421e8c6617de75a12b0d2023-03-09T12:28:47ZengCambridge University PressBJPsych Open2056-47242018-09-01434635110.1192/bjo.2018.45Cardiorespiratory fitness and response to exercise treatment in depressionMd Shafiqur Rahman0https://orcid.org/0000-0003-4068-6775Björg Helgadóttir1Mats Hallgren2Yvonne Forsell3Brendon Stubbs4Davy Vancampfort5Örjan Ekblom6Research Assistant, Department of Public Health Sciences, Karolinska Institutet, SwedenPost-Doctoral Researcher, Department of Public Health Sciences, Karolinska Institutet and Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, SwedenAssistant Professor, Department of Public Health Sciences, Karolinska Institutet, SwedenProfessor, Department of Public Health Sciences, Karolinska Institutet and Centre for Epidemiology and Community Medicine, Stockholm County Council, SwedenResearch Physiotherapist, Physiotherapy Department, South London and Maudsley NHS Foundation Trust and Health Service and Population Research Department, King's College London and Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UKPost-Doctoral Research Fellow, Department of Rehabilitation Sciences and University Psychiatric Center, KU Leuven, BelgiumAssociate Professor, Department of Sport and Health Sciences, Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, SwedenBackgroundExercise improves cardiorespiratory fitness (CRF) and reduces depressive symptoms in people with depression. It is unclear if changes in CRF are a predictor of the antidepressant effect of exercise in people with depression.AimsTo investigate whether an increase in CRF is a predictor of depression severity reduction after 12 weeks of exercise (trial registration: DRKS study ID, DRKS00008745).MethodThe present study includes participants who took part in vigorous (n = 33), moderate (n = 38) and light (n = 39) intensity exercise and had CRF information (as predicted maximal oxygen uptake, V̇O2max) collected before and after the intervention. Depression severity was measured with the Montgomery–Åsberg Depression Rating Scale (MADRS). V̇O2max (L/min) was assessed with the Åstrand–Rhyming submaximal cycle ergometry test. The main analysis was conducted pooling all exercise intensity groups together.ResultsAll exercise intensities improved V̇O2max in people with depression. Regardless of frequency and intensity of exercise, an increase in post-treatment V̇O2max was significantly associated with reduced depression severity at follow-up (B = −3.52, 95% CI −6.08 to −0.96); adjusting for intensity of exercise, age and body mass index made the association stronger (B = −3.89, 95% CI −6.53 to −1.26). Similarly, increased V̇O2max was associated with higher odds (odds ratio = 3.73, 95% CI 1.22–11.43) of exercise treatment response (≥50% reduction in MADRS score) at follow-up.ConclusionsOur data suggest that improvements in V̇O2max predict a greater reduction in depression severity among individuals who were clinically depressed. This finding indicates that improvements in V̇O2max may be a marker for the underpinning biological pathways for the antidepressant effect of exercise.Declaration of interestNone.https://www.cambridge.org/core/product/identifier/S2056472418000455/type/journal_articleDepressioncardiorespiratory fitnessexercise |
| spellingShingle | Md Shafiqur Rahman Björg Helgadóttir Mats Hallgren Yvonne Forsell Brendon Stubbs Davy Vancampfort Örjan Ekblom Cardiorespiratory fitness and response to exercise treatment in depression BJPsych Open Depression cardiorespiratory fitness exercise |
| title | Cardiorespiratory fitness and response to exercise treatment in depression |
| title_full | Cardiorespiratory fitness and response to exercise treatment in depression |
| title_fullStr | Cardiorespiratory fitness and response to exercise treatment in depression |
| title_full_unstemmed | Cardiorespiratory fitness and response to exercise treatment in depression |
| title_short | Cardiorespiratory fitness and response to exercise treatment in depression |
| title_sort | cardiorespiratory fitness and response to exercise treatment in depression |
| topic | Depression cardiorespiratory fitness exercise |
| url | https://www.cambridge.org/core/product/identifier/S2056472418000455/type/journal_article |
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