Endothelium state in Ph-negative myeloproliferative neoplasms
Thrombotic complications contribute significantly in morbidity and mortality of patients with Ph-negative myeloproliferative neoplasms (MPN) including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Vascular endothelium is essential component of hemostatic system, and its fu...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2021-12-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/695 |
| _version_ | 1826575697445912576 |
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| author | N. E. Korsakova |
| author_facet | N. E. Korsakova |
| author_sort | N. E. Korsakova |
| collection | DOAJ |
| description | Thrombotic complications contribute significantly in morbidity and mortality of patients with Ph-negative myeloproliferative neoplasms (MPN) including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Vascular endothelium is essential component of hemostatic system, and its functionality failure plays important role in prothrombotic states development. This review comprises analysis of available data on assessment of endothelium state characteristics in Ph-negative MPN and their detection with different methods. The search of literature sources was carried out using PubMed and eLibrary databases. The analysis of research results obtained with the use of different estimation techniques indicates that patients with Ph-negative MPN are characterized by endothelium activation, damage, and, consequently, dysfunction. Endothelium abnormalities associated with myeloproliferation have an effect on all endothelial functions fulfillment. Endothelial dysfunction represents important component of thrombosis pathogenesis in Ph-negative MPN. |
| first_indexed | 2024-03-08T14:32:56Z |
| format | Article |
| id | doaj.art-60afa20981e149e69b6ebf00006d71fa |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2025-03-14T13:18:49Z |
| publishDate | 2021-12-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-60afa20981e149e69b6ebf00006d71fa2025-02-28T13:43:57ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202021-12-01416304410.18699/SSMJ20210603391Endothelium state in Ph-negative myeloproliferative neoplasmsN. E. Korsakova0Russian Research Institute of Hematology and Transfusiology of FMBA of RussiaThrombotic complications contribute significantly in morbidity and mortality of patients with Ph-negative myeloproliferative neoplasms (MPN) including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Vascular endothelium is essential component of hemostatic system, and its functionality failure plays important role in prothrombotic states development. This review comprises analysis of available data on assessment of endothelium state characteristics in Ph-negative MPN and their detection with different methods. The search of literature sources was carried out using PubMed and eLibrary databases. The analysis of research results obtained with the use of different estimation techniques indicates that patients with Ph-negative MPN are characterized by endothelium activation, damage, and, consequently, dysfunction. Endothelium abnormalities associated with myeloproliferation have an effect on all endothelial functions fulfillment. Endothelial dysfunction represents important component of thrombosis pathogenesis in Ph-negative MPN.https://sibmed.elpub.ru/jour/article/view/695ph-negative myeloproliferative neoplasmsthrombosishemostasisendotheliumendothelial dysfunction |
| spellingShingle | N. E. Korsakova Endothelium state in Ph-negative myeloproliferative neoplasms Сибирский научный медицинский журнал ph-negative myeloproliferative neoplasms thrombosis hemostasis endothelium endothelial dysfunction |
| title | Endothelium state in Ph-negative myeloproliferative neoplasms |
| title_full | Endothelium state in Ph-negative myeloproliferative neoplasms |
| title_fullStr | Endothelium state in Ph-negative myeloproliferative neoplasms |
| title_full_unstemmed | Endothelium state in Ph-negative myeloproliferative neoplasms |
| title_short | Endothelium state in Ph-negative myeloproliferative neoplasms |
| title_sort | endothelium state in ph negative myeloproliferative neoplasms |
| topic | ph-negative myeloproliferative neoplasms thrombosis hemostasis endothelium endothelial dysfunction |
| url | https://sibmed.elpub.ru/jour/article/view/695 |
| work_keys_str_mv | AT nekorsakova endotheliumstateinphnegativemyeloproliferativeneoplasms |