Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis
Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, cl...
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/4/830 |
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| author | Stefania Leuci Noemi Coppola Nicola Adamo Maria Eleonora Bizzoca Daniela Russo Gianrico Spagnuolo Lorenzo Lo Muzio Michele Davide Mignogna |
| author_facet | Stefania Leuci Noemi Coppola Nicola Adamo Maria Eleonora Bizzoca Daniela Russo Gianrico Spagnuolo Lorenzo Lo Muzio Michele Davide Mignogna |
| author_sort | Stefania Leuci |
| collection | DOAJ |
| description | Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, clinical, histopathological, and therapeutic data. A group of 36 females and 9 males with a mean age of 60.3 years was evaluated. Clinically, 25 cases were bullous, a clinical phenotype never reported to date, 4 erythematous, 4 keratotic, 4 verruciform, and 3 ulcerative. On histological examination, pure polyclonal plasma cell infiltrate was detected in 20 specimens, while in 25 specimens it was associated with a mixed infiltrate. The first-line therapy consisted of oral hygiene and topical corticosteroids in all patients. In 25 patients, doxycycline and sulfasalazine were added; in 10 of these patients, the disease persisted, and it was necessary to resort to systemic steroids. This study presented the clinico-pathological profile and outcomes of a case series of PCG. This could be an aid for clinicians to be aware of the heterogeneous clinical phenotype and of the possible pure bullous phenotype of PCG. Further studies are needed to improve the knowledge about this disorder. |
| first_indexed | 2024-03-09T00:46:39Z |
| format | Article |
| id | doaj.art-60b0a5fb21414c468daa9c0890901485 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T00:46:39Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-60b0a5fb21414c468daa9c08909014852023-12-11T17:29:33ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110483010.3390/jcm10040830Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell GingivitisStefania Leuci0Noemi Coppola1Nicola Adamo2Maria Eleonora Bizzoca3Daniela Russo4Gianrico Spagnuolo5Lorenzo Lo Muzio6Michele Davide Mignogna7Department of Neurosciences, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Oral Medicine Unit, University of Naples Federico II, 80131 Naples, ItalyPlasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, clinical, histopathological, and therapeutic data. A group of 36 females and 9 males with a mean age of 60.3 years was evaluated. Clinically, 25 cases were bullous, a clinical phenotype never reported to date, 4 erythematous, 4 keratotic, 4 verruciform, and 3 ulcerative. On histological examination, pure polyclonal plasma cell infiltrate was detected in 20 specimens, while in 25 specimens it was associated with a mixed infiltrate. The first-line therapy consisted of oral hygiene and topical corticosteroids in all patients. In 25 patients, doxycycline and sulfasalazine were added; in 10 of these patients, the disease persisted, and it was necessary to resort to systemic steroids. This study presented the clinico-pathological profile and outcomes of a case series of PCG. This could be an aid for clinicians to be aware of the heterogeneous clinical phenotype and of the possible pure bullous phenotype of PCG. Further studies are needed to improve the knowledge about this disorder.https://www.mdpi.com/2077-0383/10/4/830plasma cell gingivitisplasma cell mucositisinflammationgingivitisplasma cell |
| spellingShingle | Stefania Leuci Noemi Coppola Nicola Adamo Maria Eleonora Bizzoca Daniela Russo Gianrico Spagnuolo Lorenzo Lo Muzio Michele Davide Mignogna Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis Journal of Clinical Medicine plasma cell gingivitis plasma cell mucositis inflammation gingivitis plasma cell |
| title | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
| title_full | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
| title_fullStr | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
| title_full_unstemmed | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
| title_short | Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis |
| title_sort | clinico pathological profile and outcomes of 45 cases of plasma cell gingivitis |
| topic | plasma cell gingivitis plasma cell mucositis inflammation gingivitis plasma cell |
| url | https://www.mdpi.com/2077-0383/10/4/830 |
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