The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review
Compared to an incisional skin or mucosal wound, a tooth extraction wound results in far more soft tissue loss. A blood clot instantly fills the gap left by the extracted tooth. An embryonic type of bone forms during the healing of extraction wounds, and mature bone only later replaces it. Osteocyte...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905224000063 |
| _version_ | 1797203096424677376 |
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| author | Christian Khoswanto Ira Kusuma Dewi |
| author_facet | Christian Khoswanto Ira Kusuma Dewi |
| author_sort | Christian Khoswanto |
| collection | DOAJ |
| description | Compared to an incisional skin or mucosal wound, a tooth extraction wound results in far more soft tissue loss. A blood clot instantly fills the gap left by the extracted tooth. An embryonic type of bone forms during the healing of extraction wounds, and mature bone only later replaces it. Osteocytes in embryonic bone, also known as coarse fibrillar bone or immature bone, differ from those in adult bone in terms of number, size, and irregular arrangement. This immature bone is more radiolucent than mature bone due to the higher cell density and the smaller volume of calcified intercellular material. The Wnt gene family contains genes that encode secreted signaling proteins that have good promise for promoting bone regeneration. However, we still have a limited understanding the interplay of the molecular elements of the Wnt pathway in signal transduction, from ligand detection on the cell surface to transcription of target genes in the nucleus. We discuss the function of Wnt signaling molecules in this review, in tissue repair following tooth extraction and present recent results about these molecules. Conclusions: Wnt signaling activity helps to hasten bone regeneration while bone healing is slowed down by mutations in LRP5/6 or β-catenin. |
| first_indexed | 2024-04-24T08:13:54Z |
| format | Article |
| id | doaj.art-60b331e026be412e898acaf97bce5563 |
| institution | Directory Open Access Journal |
| issn | 1013-9052 |
| language | English |
| last_indexed | 2024-04-24T08:13:54Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj.art-60b331e026be412e898acaf97bce55632024-04-17T04:48:33ZengElsevierSaudi Dental Journal1013-90522024-04-01364516520The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative reviewChristian Khoswanto0Ira Kusuma Dewi1Department of Oral Biology Faculty of Dentistry, Airlangga University Surabaya, Indonesia; Corresponding author at: Department of Oral Biology Faculty of Dentistry, Airlangga University, Jln. Mayjend. Prof. Dr. Moestopo No. 47, Surabaya 60132, Indonesia.Dentistry Clinic Research, Surabaya, IndonesiaCompared to an incisional skin or mucosal wound, a tooth extraction wound results in far more soft tissue loss. A blood clot instantly fills the gap left by the extracted tooth. An embryonic type of bone forms during the healing of extraction wounds, and mature bone only later replaces it. Osteocytes in embryonic bone, also known as coarse fibrillar bone or immature bone, differ from those in adult bone in terms of number, size, and irregular arrangement. This immature bone is more radiolucent than mature bone due to the higher cell density and the smaller volume of calcified intercellular material. The Wnt gene family contains genes that encode secreted signaling proteins that have good promise for promoting bone regeneration. However, we still have a limited understanding the interplay of the molecular elements of the Wnt pathway in signal transduction, from ligand detection on the cell surface to transcription of target genes in the nucleus. We discuss the function of Wnt signaling molecules in this review, in tissue repair following tooth extraction and present recent results about these molecules. Conclusions: Wnt signaling activity helps to hasten bone regeneration while bone healing is slowed down by mutations in LRP5/6 or β-catenin.http://www.sciencedirect.com/science/article/pii/S1013905224000063Wnt SignalingTooth ExtractionWound Healing |
| spellingShingle | Christian Khoswanto Ira Kusuma Dewi The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review Saudi Dental Journal Wnt Signaling Tooth Extraction Wound Healing |
| title | The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review |
| title_full | The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review |
| title_fullStr | The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review |
| title_full_unstemmed | The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review |
| title_short | The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review |
| title_sort | role of wnt signaling on tooth extraction wound healing narrative review |
| topic | Wnt Signaling Tooth Extraction Wound Healing |
| url | http://www.sciencedirect.com/science/article/pii/S1013905224000063 |
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