Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection
We propose a fractional order model to study the efficacy of the Post-Exposure Prophylaxis (PEP) in human immunodeficiency virus (HIV) within-host dynamics, in the presence of the HIV latent reservoir. Latent reservoirs harbor infected cells that contain a transcriptionally silent but reactivatable...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/7/6/515 |
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| author | Carla M. A. Pinto Ana R. M. Carvalho Dumitru Baleanu Hari M. Srivastava |
| author_facet | Carla M. A. Pinto Ana R. M. Carvalho Dumitru Baleanu Hari M. Srivastava |
| author_sort | Carla M. A. Pinto |
| collection | DOAJ |
| description | We propose a fractional order model to study the efficacy of the Post-Exposure Prophylaxis (PEP) in human immunodeficiency virus (HIV) within-host dynamics, in the presence of the HIV latent reservoir. Latent reservoirs harbor infected cells that contain a transcriptionally silent but reactivatable provirus. The latter constitutes a major difficulty to the eradication of HIV in infected patients. PEP is used as a way to prevent HIV infection after a recent possible exposure to HIV. It consists of the in-take of antiretroviral drugs for, usually, 28 days. In this study, we focus on the dosage and dosage intervals of antiretroviral therapy (ART) during PEP and in the role of the latent reservoir in HIV infected patients. We thus simulate the model for immunologically important parameters concerning the drugs and the fraction of latently infected cells. The results may add important information to clinical practice of HIV infected patients. |
| first_indexed | 2024-12-12T03:01:29Z |
| format | Article |
| id | doaj.art-60b5db568ba24008a98a395b9796ecab |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-12-12T03:01:29Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj.art-60b5db568ba24008a98a395b9796ecab2022-12-22T00:40:37ZengMDPI AGMathematics2227-73902019-06-017651510.3390/math7060515math7060515Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV InfectionCarla M. A. Pinto0Ana R. M. Carvalho1Dumitru Baleanu2Hari M. Srivastava3School of Engineering, Polytechnic of Porto, Rua Dr António Bernardino de Almeida, 431, 4200-072 Porto, PortugalFaculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4440-452 Porto, PortugalDepartment of Mathematics and Computer Sciences, Cankaya University, Balgat, Ankara 0630, TurkeyDepartment of Mathematics and Statistics, University of Victoria, Victoria, BC V8W 3R4, CanadaWe propose a fractional order model to study the efficacy of the Post-Exposure Prophylaxis (PEP) in human immunodeficiency virus (HIV) within-host dynamics, in the presence of the HIV latent reservoir. Latent reservoirs harbor infected cells that contain a transcriptionally silent but reactivatable provirus. The latter constitutes a major difficulty to the eradication of HIV in infected patients. PEP is used as a way to prevent HIV infection after a recent possible exposure to HIV. It consists of the in-take of antiretroviral drugs for, usually, 28 days. In this study, we focus on the dosage and dosage intervals of antiretroviral therapy (ART) during PEP and in the role of the latent reservoir in HIV infected patients. We thus simulate the model for immunologically important parameters concerning the drugs and the fraction of latently infected cells. The results may add important information to clinical practice of HIV infected patients.https://www.mdpi.com/2227-7390/7/6/515Post-Exposure Prophylaxislatent reservoirHIV infectionfractional order model |
| spellingShingle | Carla M. A. Pinto Ana R. M. Carvalho Dumitru Baleanu Hari M. Srivastava Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection Mathematics Post-Exposure Prophylaxis latent reservoir HIV infection fractional order model |
| title | Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection |
| title_full | Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection |
| title_fullStr | Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection |
| title_full_unstemmed | Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection |
| title_short | Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection |
| title_sort | efficacy of the post exposure prophylaxis and of the hiv latent reservoir in hiv infection |
| topic | Post-Exposure Prophylaxis latent reservoir HIV infection fractional order model |
| url | https://www.mdpi.com/2227-7390/7/6/515 |
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