Drug Burden Index in older adults: theoretical and practical issues
Lisa Kouladjian,1 Danijela Gnjidic,1,2 Timothy F Chen,2 Arduino A Mangoni,3 Sarah N Hilmer1 1Sydney Medical School, University of Sydney, Kolling Institute of Medical Research and Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, 2Faculty of Pharmacy, University of Syd...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014-09-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/drug-burden-index-in-older-adults-theoretical-and-practical-issues-peer-reviewed-article-CIA |
| _version_ | 1818996680207368192 |
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| author | Kouladjian L Gnjidic D Chen TF Mangoni AA Hilmer SN |
| author_facet | Kouladjian L Gnjidic D Chen TF Mangoni AA Hilmer SN |
| author_sort | Kouladjian L |
| collection | DOAJ |
| description | Lisa Kouladjian,1 Danijela Gnjidic,1,2 Timothy F Chen,2 Arduino A Mangoni,3 Sarah N Hilmer1 1Sydney Medical School, University of Sydney, Kolling Institute of Medical Research and Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, 2Faculty of Pharmacy, University of Sydney, Sydney, NSW, 3Department of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Bedford Park, SA, Australia Abstract: Anticholinergic and sedative medications are commonly used in older adults and are associated with adverse clinical outcomes. The Drug Burden Index was developed to measure the cumulative exposure to these medications in older adults and its impact on physical and cognitive function. This narrative review discusses the research and clinical applications of the Drug Burden Index, and its advantages and limitations, compared with other pharmacologically developed measures of high-risk prescribing. Keywords: Drug Burden Index, anticholinergics, sedative medications, high-risk prescribing, older adults, pharmacological risk assessment tools, deprescribing |
| first_indexed | 2024-12-20T21:33:35Z |
| format | Article |
| id | doaj.art-60b8be218d384aebb8c39ee775e78837 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-20T21:33:35Z |
| publishDate | 2014-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-60b8be218d384aebb8c39ee775e788372022-12-21T19:26:00ZengDove Medical PressClinical Interventions in Aging1178-19982014-09-01Volume 91503151518269Drug Burden Index in older adults: theoretical and practical issuesKouladjian LGnjidic DChen TFMangoni AAHilmer SNLisa Kouladjian,1 Danijela Gnjidic,1,2 Timothy F Chen,2 Arduino A Mangoni,3 Sarah N Hilmer1 1Sydney Medical School, University of Sydney, Kolling Institute of Medical Research and Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, 2Faculty of Pharmacy, University of Sydney, Sydney, NSW, 3Department of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Bedford Park, SA, Australia Abstract: Anticholinergic and sedative medications are commonly used in older adults and are associated with adverse clinical outcomes. The Drug Burden Index was developed to measure the cumulative exposure to these medications in older adults and its impact on physical and cognitive function. This narrative review discusses the research and clinical applications of the Drug Burden Index, and its advantages and limitations, compared with other pharmacologically developed measures of high-risk prescribing. Keywords: Drug Burden Index, anticholinergics, sedative medications, high-risk prescribing, older adults, pharmacological risk assessment tools, deprescribinghttps://www.dovepress.com/drug-burden-index-in-older-adults-theoretical-and-practical-issues-peer-reviewed-article-CIADrug Burden Indexanticholinergic and sedative medicationshigh-risk prescribingolder adultspharmacological risk assessment toolspotentially inappropriate medications |
| spellingShingle | Kouladjian L Gnjidic D Chen TF Mangoni AA Hilmer SN Drug Burden Index in older adults: theoretical and practical issues Clinical Interventions in Aging Drug Burden Index anticholinergic and sedative medications high-risk prescribing older adults pharmacological risk assessment tools potentially inappropriate medications |
| title | Drug Burden Index in older adults: theoretical and practical issues |
| title_full | Drug Burden Index in older adults: theoretical and practical issues |
| title_fullStr | Drug Burden Index in older adults: theoretical and practical issues |
| title_full_unstemmed | Drug Burden Index in older adults: theoretical and practical issues |
| title_short | Drug Burden Index in older adults: theoretical and practical issues |
| title_sort | drug burden index in older adults theoretical and practical issues |
| topic | Drug Burden Index anticholinergic and sedative medications high-risk prescribing older adults pharmacological risk assessment tools potentially inappropriate medications |
| url | https://www.dovepress.com/drug-burden-index-in-older-adults-theoretical-and-practical-issues-peer-reviewed-article-CIA |
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