Identifying the Novel Inhibitors Against the Mycolic Acid Biosynthesis Pathway Target “mtFabH” of Mycobacterium tuberculosis

Identifying the Novel Inhibitors Against the Mycolic Acid Biosynthesis Pathway Target “mtFabH” of Mycobacterium tuberculosis

Mycolic acids are the key constituents of mycobacterial cell wall, which protect the bacteria from antibiotic susceptibility, helping to subvert and escape from the host immune system. Thus, the enzymes involved in regulating and biosynthesis of mycolic acids can be explored as potential drug target...

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Bibliographic Details
Main Authors: Niranjan Kumar, Rakesh Srivastava, Raj Kumar Mongre, Chandra Bhushan Mishra, Amit Kumar, Rosy Khatoon, Atanu Banerjee, Md Ashraf-Uz-Zaman, Harpreet Singh, Andrew M. Lynn, Myeong-Sok Lee, Amresh Prakash
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
mycolic acids
mtFabH
inhibitor
MD simulation
MM/PBSA
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.818714/full

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