Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study
Binbin Zhao,1,* Yanhua Wu,2,* Xiaoying Jin,1 Lihong Yang,2 Jian Yang,1,2 Xiancang Ma,1 Bin Yan1,2 1Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, The First Affiliated Ho...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-08-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/objectively-measured-sleep-characteristics-and-incidence-of-ischemic-s-peer-reviewed-fulltext-article-NSS |
| _version_ | 1818991903229607936 |
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| author | Zhao B Wu Y Jin X Yang L Yang J Ma X Yan B |
| author_facet | Zhao B Wu Y Jin X Yang L Yang J Ma X Yan B |
| author_sort | Zhao B |
| collection | DOAJ |
| description | Binbin Zhao,1,* Yanhua Wu,2,* Xiaoying Jin,1 Lihong Yang,2 Jian Yang,1,2 Xiancang Ma,1 Bin Yan1,2 1Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin YanDepartment of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaTel +86 2985323614Email yanbin.1987@hotmail.comObjective: Sleep disorders are associated with the prevalence of stroke. However, there is limited evidence regarding the association between objectively measured sleep characteristics and ischemic stroke.Methods: Ischemic stroke was assessed during the mean follow-up period of 11 years in the Sleep Heart Health Study. Sleep parameters such as wake after sleep onset (WASO) and sleep efficiency (SE) were objectively measured based on in-home polysomnography records. Multivariable Cox regression analysis was utilized to examine the relationship between objective sleep characteristics and ischemic stroke incidence.Results: This study involved 4204 participants (1978 males and 2226 females, 63.8± 11.1 years). The incidence of ischemic stroke increased in individuals with long WASO, poor SE, and short sleep duration. Multivariable Cox regression analysis showed that WASO within the fourth quartile (hazard ratio [HR] 3.771, 95% confidence interval [CI] 1.805– 7.877, P< 0.001), third quartile (HR 3.009, 95% CI 1.433– 6.317, P=0.004), and second quartile (HR 3.108, 95% CI 1.470– 6.568, P=0.003) had a higher incidence of ischemic stroke than WASO within the first quartile. Poor SE (< 80.0%) was also found to be a predictor for ischemic stroke (HR 2.220, 95% CI 1.244– 3.960, P=0.007). Additionally, a short sleep duration (< 6 h) was associated with an increased risk of ischemic stroke (HR 1.725, 95% CI 1.026– 2.899, P=0.040).Conclusion: Our results revealed a relationship between WASO, SE, and sleep duration and ischemic stroke. Therefore, these sleep characteristics may be adequate predictors for the incidence of ischemic stroke.Keywords: sleep characteristics, ischemic stroke, polysomnography, Sleep Heart Health Study |
| first_indexed | 2024-12-20T20:17:39Z |
| format | Article |
| id | doaj.art-60bad220056c4bf283eb00ff0f5c65eb |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-12-20T20:17:39Z |
| publishDate | 2021-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-60bad220056c4bf283eb00ff0f5c65eb2022-12-21T19:27:40ZengDove Medical PressNature and Science of Sleep1179-16082021-08-01Volume 131485149468171Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health StudyZhao BWu YJin XYang LYang JMa XYan BBinbin Zhao,1,* Yanhua Wu,2,* Xiaoying Jin,1 Lihong Yang,2 Jian Yang,1,2 Xiancang Ma,1 Bin Yan1,2 1Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin YanDepartment of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaTel +86 2985323614Email yanbin.1987@hotmail.comObjective: Sleep disorders are associated with the prevalence of stroke. However, there is limited evidence regarding the association between objectively measured sleep characteristics and ischemic stroke.Methods: Ischemic stroke was assessed during the mean follow-up period of 11 years in the Sleep Heart Health Study. Sleep parameters such as wake after sleep onset (WASO) and sleep efficiency (SE) were objectively measured based on in-home polysomnography records. Multivariable Cox regression analysis was utilized to examine the relationship between objective sleep characteristics and ischemic stroke incidence.Results: This study involved 4204 participants (1978 males and 2226 females, 63.8± 11.1 years). The incidence of ischemic stroke increased in individuals with long WASO, poor SE, and short sleep duration. Multivariable Cox regression analysis showed that WASO within the fourth quartile (hazard ratio [HR] 3.771, 95% confidence interval [CI] 1.805– 7.877, P< 0.001), third quartile (HR 3.009, 95% CI 1.433– 6.317, P=0.004), and second quartile (HR 3.108, 95% CI 1.470– 6.568, P=0.003) had a higher incidence of ischemic stroke than WASO within the first quartile. Poor SE (< 80.0%) was also found to be a predictor for ischemic stroke (HR 2.220, 95% CI 1.244– 3.960, P=0.007). Additionally, a short sleep duration (< 6 h) was associated with an increased risk of ischemic stroke (HR 1.725, 95% CI 1.026– 2.899, P=0.040).Conclusion: Our results revealed a relationship between WASO, SE, and sleep duration and ischemic stroke. Therefore, these sleep characteristics may be adequate predictors for the incidence of ischemic stroke.Keywords: sleep characteristics, ischemic stroke, polysomnography, Sleep Heart Health Studyhttps://www.dovepress.com/objectively-measured-sleep-characteristics-and-incidence-of-ischemic-s-peer-reviewed-fulltext-article-NSSsleep characteristicsischemic strokepolysomnographysleep heart health study |
| spellingShingle | Zhao B Wu Y Jin X Yang L Yang J Ma X Yan B Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study Nature and Science of Sleep sleep characteristics ischemic stroke polysomnography sleep heart health study |
| title | Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study |
| title_full | Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study |
| title_fullStr | Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study |
| title_full_unstemmed | Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study |
| title_short | Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study |
| title_sort | objectively measured sleep characteristics and incidence of ischemic stroke the sleep heart health study |
| topic | sleep characteristics ischemic stroke polysomnography sleep heart health study |
| url | https://www.dovepress.com/objectively-measured-sleep-characteristics-and-incidence-of-ischemic-s-peer-reviewed-fulltext-article-NSS |
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