Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis.
BACKGROUND:Inflammatory markers are used to predict prognosis of nasopharyngeal carcinoma (NPC). Previous reports of neutrophil-to-lymphocyte ratio (NLR) and NPC mortality are inconsistent. This study aimed to quantify the prognostic impact of NLR on NPC. METHODS:The primary outcome was overall surv...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5513538?pdf=render |
| _version_ | 1818305073180049408 |
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| author | Yukinori Takenaka Takahiro Kitamura Ryohei Oya Naoki Ashida Kotaro Shimizu Kazuya Takemura Yoshifumi Yamamoto Atsuhiko Uno |
| author_facet | Yukinori Takenaka Takahiro Kitamura Ryohei Oya Naoki Ashida Kotaro Shimizu Kazuya Takemura Yoshifumi Yamamoto Atsuhiko Uno |
| author_sort | Yukinori Takenaka |
| collection | DOAJ |
| description | BACKGROUND:Inflammatory markers are used to predict prognosis of nasopharyngeal carcinoma (NPC). Previous reports of neutrophil-to-lymphocyte ratio (NLR) and NPC mortality are inconsistent. This study aimed to quantify the prognostic impact of NLR on NPC. METHODS:The primary outcome was overall survival (OS), and the secondary outcomes were disease-specific survival (DSS), progression-free survival (PFS) and distant metastasis-free survival (DMFS). We systematically searched electronic databases, identified articles reporting an association between NLR and NPC prognosis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted, and pooled HRs for each outcome were estimated using random effect models. RESULTS:Nine studies enrolling 5397 patients were included in the analyses. NLR greater than the cutoff value was associated with poor overall survival (HR 1.51, 95% CI 1.27-1.78), disease-specific survival (HR 1.44, 95% CI 1.22-1.71), progression-free survival (HR 1.53, 95% CI 1.22-1.90), and distant metastasis-free survival (HR 1.83, 95% CI 1.14-2.95). CONCLUSIONS:Elevated NLR predicts worse OS, DSS, PFS and DMFS in patients with NPC. |
| first_indexed | 2024-12-13T06:20:47Z |
| format | Article |
| id | doaj.art-60bca17c0c4c49bd859972e4988b7995 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T06:20:47Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-60bca17c0c4c49bd859972e4988b79952022-12-21T23:56:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018147810.1371/journal.pone.0181478Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis.Yukinori TakenakaTakahiro KitamuraRyohei OyaNaoki AshidaKotaro ShimizuKazuya TakemuraYoshifumi YamamotoAtsuhiko UnoBACKGROUND:Inflammatory markers are used to predict prognosis of nasopharyngeal carcinoma (NPC). Previous reports of neutrophil-to-lymphocyte ratio (NLR) and NPC mortality are inconsistent. This study aimed to quantify the prognostic impact of NLR on NPC. METHODS:The primary outcome was overall survival (OS), and the secondary outcomes were disease-specific survival (DSS), progression-free survival (PFS) and distant metastasis-free survival (DMFS). We systematically searched electronic databases, identified articles reporting an association between NLR and NPC prognosis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted, and pooled HRs for each outcome were estimated using random effect models. RESULTS:Nine studies enrolling 5397 patients were included in the analyses. NLR greater than the cutoff value was associated with poor overall survival (HR 1.51, 95% CI 1.27-1.78), disease-specific survival (HR 1.44, 95% CI 1.22-1.71), progression-free survival (HR 1.53, 95% CI 1.22-1.90), and distant metastasis-free survival (HR 1.83, 95% CI 1.14-2.95). CONCLUSIONS:Elevated NLR predicts worse OS, DSS, PFS and DMFS in patients with NPC.http://europepmc.org/articles/PMC5513538?pdf=render |
| spellingShingle | Yukinori Takenaka Takahiro Kitamura Ryohei Oya Naoki Ashida Kotaro Shimizu Kazuya Takemura Yoshifumi Yamamoto Atsuhiko Uno Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis. PLoS ONE |
| title | Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis. |
| title_full | Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis. |
| title_fullStr | Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis. |
| title_full_unstemmed | Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis. |
| title_short | Prognostic role of neutrophil-lymphocyte ratio in nasopharyngeal carcinoma: A meta-analysis. |
| title_sort | prognostic role of neutrophil lymphocyte ratio in nasopharyngeal carcinoma a meta analysis |
| url | http://europepmc.org/articles/PMC5513538?pdf=render |
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