Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis

Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis

IntroductionDefective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underlying this lymphatic dysfunction remain poorly understood. Here...

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Main Authors: H. Mark Kenney, Javier Rangel-Moreno, Yue Peng, Kiana L. Chen, Jennifer Bruno, Abdul Embong, Elizabeth Pritchett, Jeffrey I. Fox, Enrique Becerril-Villanueva, Armando Gamboa-Domínguez, Sally Quataert, Gowrishankar Muthukrishnan, Ronald W. Wood, Benjamin D. Korman, Jennifer H. Anolik, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz, Chia-Lung Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
spatial transcriptomics
single-cell RNA sequencing
plasma cells
B-cells
arthritis
lymph node
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237498/full

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