Determining the Anticancer Activity of Sphingosine Kinase Inhibitors Containing Heteroatoms in Their Tail Structure

Determining the Anticancer Activity of Sphingosine Kinase Inhibitors Containing Heteroatoms in Their Tail Structure

Sphingosine kinase (SK) enzyme, a central player of sphingolipid rheostat, catalyzes the phosphorylation of sphingosine to the bioactive lipid mediator sphingosine 1 phosphate (S1P), which regulates cancer cell proliferation, migration, differentiation, and angiogenesis through its extracellular fiv...

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Bibliographic Details
Main Authors: Jitendra Shrestha, Seong Woong Kim, Su-Bin Kim, Yoon Sin Oh, Sung Hwan Ki, Taeho Lee, Sang-Bum Kim, Taeuk Park, Dong Jae Baek, Eun-Young Park
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
SK inhibitor
colorectal cancer
S1P
derivative
anticancer agent
PP2A
Online Access:https://www.mdpi.com/1999-4923/14/1/157

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