Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein

Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein

The microsomal triglyceride transfer protein (MTP) is essential for the secretion of apolipoprotein B (apoB)48- and apoB100-containing lipoproteins in the intestine and liver, respectively. Loss of function mutations in MTP cause abetalipoproteinemia. Heterologous cells are used to evaluate the func...

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Bibliographic Details
Main Authors: Narasimha Anaganti, Atrayee Chattopadhyay, John T. Poirier, M. Mahmood Hussain
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Lipid Research
Subjects:
electroporation
ribonucleoprotein complex
gene ablation
apoB100
lipoprotein assembly and secretion
CRISPR/Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000906

Internet

http://www.sciencedirect.com/science/article/pii/S0022227522000906

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