Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case series
Feline sporotrichosis is a major clinical problem among cats in Brazil and is also a neglected, but important, public health issue, due to its zoonotic potential. The nasal clinical form of the disease is particularly challenging, having treatment refractoriness and clinical signs relapse as common...
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| Format: | Article |
| Language: | English |
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Sociedade de Medicina Veterinária do Estado do Rio de Janeiro
2022-05-01
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| Series: | Brazilian Journal of Veterinary Medicine |
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| Online Access: | https://bjvm.org.br/BJVM/article/view/1242 |
| _version_ | 1827952453834768384 |
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| author | Julia Possebon Santi Carla Regina Gomes Rodrigues Santos Arthur Saturiano dos Santos Heloísa Justen Moreira Souza |
| author_facet | Julia Possebon Santi Carla Regina Gomes Rodrigues Santos Arthur Saturiano dos Santos Heloísa Justen Moreira Souza |
| author_sort | Julia Possebon Santi |
| collection | DOAJ |
| description | Feline sporotrichosis is a major clinical problem among cats in Brazil and is also a neglected, but important, public health issue, due to its zoonotic potential. The nasal clinical form of the disease is particularly challenging, having treatment refractoriness and clinical signs relapse as common features. This case series study aimed to preliminarily describe the effects of the azolic antifungal drug, clotrimazole, as a topical 1% solution spray, together with per os itraconazole on inducing disease remission, as well as treatment tolerability and safety. Medical records of the Feline Medicine Service from the Universidade Federal Rural do Rio de Janeiro were reviewed, and 7 feline patients met the inclusion criteria (confirmatory diagnostic reached, available follow-up records, and use of intranasal clotrimazole 1% solution –1 spray per nostril every 24 hours– as adjunctive therapy to itraconazole – 100 mg/cat per os every 24 hours). Among these, 4 had a history of treatment refractoriness done until then. Follow-up records included clinical evaluation, along with complementary tests and owner reports on tolerability and occurrence of adverse reactions. All patients have undergone clinical remission within 60 days. Tolerability were satisfactory, and adverse reactions were only found on complementary tests (hepatic enzyme elevation), without clinical repercussion. The intranasal use of 1% clotrimazole solution has shown as a promising adjunctive therapy to itraconazole for feline nasal sporotrichosis, even in previous refractory cases. |
| first_indexed | 2024-04-09T13:57:47Z |
| format | Article |
| id | doaj.art-60bd97360659475f9fc58967dcd194ab |
| institution | Directory Open Access Journal |
| issn | 0100-2430 2527-2179 |
| language | English |
| last_indexed | 2024-04-09T13:57:47Z |
| publishDate | 2022-05-01 |
| publisher | Sociedade de Medicina Veterinária do Estado do Rio de Janeiro |
| record_format | Article |
| series | Brazilian Journal of Veterinary Medicine |
| spelling | doaj.art-60bd97360659475f9fc58967dcd194ab2023-05-07T12:41:28ZengSociedade de Medicina Veterinária do Estado do Rio de JaneiroBrazilian Journal of Veterinary Medicine0100-24302527-21792022-05-0144e004821e00482110.29374/2527-2179.bjvm0048211117Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case seriesJulia Possebon Santi0https://orcid.org/0000-0003-3389-6125Carla Regina Gomes Rodrigues Santos1https://orcid.org/0000-0002-0830-0046Arthur Saturiano dos Santos2https://orcid.org/0000-0002-0912-2333Heloísa Justen Moreira Souza3https://orcid.org/0000-0002-4077-5981Veterinarian, Resident, Programa de Residência em Medicina Veterinária – Clínica Médica dos Gatos Domésticos. Departamento de Medicina e Cirurgia Veterinária (DMCV), Instituto de Veterinária (IV), Universidade Federal Rural do Rio de Janeiro (UFRRJ). Campus Seropédica, RJ, Brazil. Veterinarian, MSc. Programa de Pós-Graduação em Medicina Veterinária (PPGMV), DMCV, IV, UFRRJ. Campus Seropédica, RJ, Brazil. Undergraduate in Veterinary Medicine, IV, UFRRJ. Campus Seropédica, RJ, Brazil.Veterinarian, DSc. DMCV, IV, UFRRJ. Campus Seropédica, RJ, Brazil.Feline sporotrichosis is a major clinical problem among cats in Brazil and is also a neglected, but important, public health issue, due to its zoonotic potential. The nasal clinical form of the disease is particularly challenging, having treatment refractoriness and clinical signs relapse as common features. This case series study aimed to preliminarily describe the effects of the azolic antifungal drug, clotrimazole, as a topical 1% solution spray, together with per os itraconazole on inducing disease remission, as well as treatment tolerability and safety. Medical records of the Feline Medicine Service from the Universidade Federal Rural do Rio de Janeiro were reviewed, and 7 feline patients met the inclusion criteria (confirmatory diagnostic reached, available follow-up records, and use of intranasal clotrimazole 1% solution –1 spray per nostril every 24 hours– as adjunctive therapy to itraconazole – 100 mg/cat per os every 24 hours). Among these, 4 had a history of treatment refractoriness done until then. Follow-up records included clinical evaluation, along with complementary tests and owner reports on tolerability and occurrence of adverse reactions. All patients have undergone clinical remission within 60 days. Tolerability were satisfactory, and adverse reactions were only found on complementary tests (hepatic enzyme elevation), without clinical repercussion. The intranasal use of 1% clotrimazole solution has shown as a promising adjunctive therapy to itraconazole for feline nasal sporotrichosis, even in previous refractory cases.https://bjvm.org.br/BJVM/article/view/1242azolic antifungal, subcutaneous mycosis, sporothrix brasiliensis, nasal granuloma. |
| spellingShingle | Julia Possebon Santi Carla Regina Gomes Rodrigues Santos Arthur Saturiano dos Santos Heloísa Justen Moreira Souza Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case series Brazilian Journal of Veterinary Medicine azolic antifungal, subcutaneous mycosis, sporothrix brasiliensis, nasal granuloma. |
| title | Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case series |
| title_full | Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case series |
| title_fullStr | Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case series |
| title_full_unstemmed | Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case series |
| title_short | Intranasal clotrimazole spray 1% associated with oral itraconazole for nasal feline sporotrichosis: a case series |
| title_sort | intranasal clotrimazole spray 1 associated with oral itraconazole for nasal feline sporotrichosis a case series |
| topic | azolic antifungal, subcutaneous mycosis, sporothrix brasiliensis, nasal granuloma. |
| url | https://bjvm.org.br/BJVM/article/view/1242 |
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