Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

Abstract Background We propose a new approach for designing personalized treatment for colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with mathematical modeling of the results. Methods The validated phenotypic approach called Therapeutically Guided Multidrug Optimiz...

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Bibliographic Details
Main Authors: George M. Ramzy, Maxim Norkin, Thibaud Koessler, Lionel Voirol, Mathieu Tihy, Dina Hany, Thomas McKee, Frédéric Ris, Nicolas Buchs, Mylène Docquier, Christian Toso, Laura Rubbia-Brandt, Gaetan Bakalli, Stéphane Guerrier, Joerg Huelsken, Patrycja Nowak-Sliwinska
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Drug-drug interaction
Drug resistance
Multidrug combination
Organoid
Phenotypic screen
Synergy
Online Access:https://doi.org/10.1186/s13046-023-02650-z

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