Disease resistance and infectivity of virus susceptible and resistant common carp strains
Abstract Infectious diseases challenge health and welfare of humans and animals. Unlike for humans, breeding of genetically resistant animals is a sustainable solution, also providing unique research opportunities. Chances to survive a disease are improved by disease resistance, but depend also on c...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-55133-2 |
| _version_ | 1797275006489591808 |
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| author | Batya Dorfman Evgeniya Marcos-Hadad Roni Tadmor-Levi Lior David |
| author_facet | Batya Dorfman Evgeniya Marcos-Hadad Roni Tadmor-Levi Lior David |
| author_sort | Batya Dorfman |
| collection | DOAJ |
| description | Abstract Infectious diseases challenge health and welfare of humans and animals. Unlike for humans, breeding of genetically resistant animals is a sustainable solution, also providing unique research opportunities. Chances to survive a disease are improved by disease resistance, but depend also on chances to get infected and infect others. Considerable knowledge exists on chances of susceptible and resistant animals to survive a disease, yet, almost none on their infectivity and if and how resistance and infectivity correlate. Common carp (Cyprinus carpio) is widely produced in aquaculture, suffering significantly from a disease caused by cyprinid herpes virus type 3 (CyHV-3). Here, the infectivity of disease-resistant and susceptible fish types was tested by playing roles of shedders (infecting) and cohabitants (infected) in all four type-role combinations. Resistant shedders restricted spleen viral load and survived more than susceptible ones. However, mortality of susceptible cohabitants infected by resistant shedders was lower than that of resistant cohabitants infected by susceptible shedders. Virus levels in water were lower in tanks with resistant shedders leading to lower spleen viral loads in cohabitants. Thus, we empirically demonstrated that disease resistant fish survive better and infect less, with implications to epidemiology in general and to the benefit of aquaculture production. |
| first_indexed | 2024-03-07T15:07:12Z |
| format | Article |
| id | doaj.art-60bf64dac6be471789bbe41e2260725a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:07:12Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-60bf64dac6be471789bbe41e2260725a2024-03-05T18:51:30ZengNature PortfolioScientific Reports2045-23222024-02-0114111210.1038/s41598-024-55133-2Disease resistance and infectivity of virus susceptible and resistant common carp strainsBatya Dorfman0Evgeniya Marcos-Hadad1Roni Tadmor-Levi2Lior David3Department of Animal Sciences, RH Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemDepartment of Animal Sciences, RH Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemDepartment of Animal Sciences, RH Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemDepartment of Animal Sciences, RH Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemAbstract Infectious diseases challenge health and welfare of humans and animals. Unlike for humans, breeding of genetically resistant animals is a sustainable solution, also providing unique research opportunities. Chances to survive a disease are improved by disease resistance, but depend also on chances to get infected and infect others. Considerable knowledge exists on chances of susceptible and resistant animals to survive a disease, yet, almost none on their infectivity and if and how resistance and infectivity correlate. Common carp (Cyprinus carpio) is widely produced in aquaculture, suffering significantly from a disease caused by cyprinid herpes virus type 3 (CyHV-3). Here, the infectivity of disease-resistant and susceptible fish types was tested by playing roles of shedders (infecting) and cohabitants (infected) in all four type-role combinations. Resistant shedders restricted spleen viral load and survived more than susceptible ones. However, mortality of susceptible cohabitants infected by resistant shedders was lower than that of resistant cohabitants infected by susceptible shedders. Virus levels in water were lower in tanks with resistant shedders leading to lower spleen viral loads in cohabitants. Thus, we empirically demonstrated that disease resistant fish survive better and infect less, with implications to epidemiology in general and to the benefit of aquaculture production.https://doi.org/10.1038/s41598-024-55133-2 |
| spellingShingle | Batya Dorfman Evgeniya Marcos-Hadad Roni Tadmor-Levi Lior David Disease resistance and infectivity of virus susceptible and resistant common carp strains Scientific Reports |
| title | Disease resistance and infectivity of virus susceptible and resistant common carp strains |
| title_full | Disease resistance and infectivity of virus susceptible and resistant common carp strains |
| title_fullStr | Disease resistance and infectivity of virus susceptible and resistant common carp strains |
| title_full_unstemmed | Disease resistance and infectivity of virus susceptible and resistant common carp strains |
| title_short | Disease resistance and infectivity of virus susceptible and resistant common carp strains |
| title_sort | disease resistance and infectivity of virus susceptible and resistant common carp strains |
| url | https://doi.org/10.1038/s41598-024-55133-2 |
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