Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital
The study of antimicrobial-resistant Propionibacterium acnes was not conducted regularly, especially in Indonesia. Conversely, regular monitoring of antibiotic efficacy through in vitro testing to assess the evolution of current resistance patterns is obligated; thus, filling the gap caused by a lac...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=4;spage=488;epage=488;aulast=Gozali |
| _version_ | 1797649362813190144 |
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| author | Maria Mayfinna Gozali Yuli Kurniawati Mutia Devi Erial Bahar Lisa Dewi Yulia Farida Yahya Rusmawardiana Sarah Diba Zulkarnain Soenarto Kartowigno |
| author_facet | Maria Mayfinna Gozali Yuli Kurniawati Mutia Devi Erial Bahar Lisa Dewi Yulia Farida Yahya Rusmawardiana Sarah Diba Zulkarnain Soenarto Kartowigno |
| author_sort | Maria Mayfinna Gozali |
| collection | DOAJ |
| description | The study of antimicrobial-resistant Propionibacterium acnes was not conducted regularly, especially in Indonesia. Conversely, regular monitoring of antibiotic efficacy through in vitro testing to assess the evolution of current resistance patterns is obligated; thus, filling the gap caused by a lack of appropriate antibiotic surveillance is required. Analyse the correlation between resistance patterns of P. acnes to doxycycline, clindamycin, erythromycin and azithromycin with the severity of acne vulgaris. This is an analytic observational laboratory study with a cross-sectional design of mild to severe acne vulgaris (AV) patients. Specimens were obtained from comedones of 71 patients, which were cultured and identified using biochemical examination. Antimicrobial resistance (doxycycline, clindamycin, erythromycin and azithromycin) to P. acnes was tested by disc diffusion method. Among 71 samples collected, 40 (56.3%) P. acnes isolates were cultured and identified. The incidence of P. acnes resistance to more than one antimicrobial was 45%. Antimicrobial resistances were clindamycin 42.5%, erythromycin 40%, azithromycin 23.5% and doxycycline 12.5%, respectively. According to the contingency coefficient test, there was moderate correlation between the resistance pattern of P. acnes to clindamycin (r = 0.485, P = <0.001) and doxycycline (r = 0.433, P = 0.002) and AV severity. There was weak correlation between the resistance pattern of P. acnes to erythromycin (r = 0.333; P = 0.025) and azithromycin (r = 0.321; P = 0.032) and AV severity. In conclusion, there is a correlation between the pattern of P. acnes resistance to doxycycline, clindamycin, erythromycin, azithromycin and severity of AV. |
| first_indexed | 2024-03-11T15:45:07Z |
| format | Article |
| id | doaj.art-60c1eaa79f78406a8e57ac428d36b146 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-03-11T15:45:07Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-60c1eaa79f78406a8e57ac428d36b1462023-10-26T06:34:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112023-01-0168448848810.4103/ijd.ijd_623_22Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospitalMaria Mayfinna GozaliYuli KurniawatiMutia DeviErial BaharLisa DewiYulia Farida YahyaRusmawardianaSarah Diba ZulkarnainSoenarto KartowignoThe study of antimicrobial-resistant Propionibacterium acnes was not conducted regularly, especially in Indonesia. Conversely, regular monitoring of antibiotic efficacy through in vitro testing to assess the evolution of current resistance patterns is obligated; thus, filling the gap caused by a lack of appropriate antibiotic surveillance is required. Analyse the correlation between resistance patterns of P. acnes to doxycycline, clindamycin, erythromycin and azithromycin with the severity of acne vulgaris. This is an analytic observational laboratory study with a cross-sectional design of mild to severe acne vulgaris (AV) patients. Specimens were obtained from comedones of 71 patients, which were cultured and identified using biochemical examination. Antimicrobial resistance (doxycycline, clindamycin, erythromycin and azithromycin) to P. acnes was tested by disc diffusion method. Among 71 samples collected, 40 (56.3%) P. acnes isolates were cultured and identified. The incidence of P. acnes resistance to more than one antimicrobial was 45%. Antimicrobial resistances were clindamycin 42.5%, erythromycin 40%, azithromycin 23.5% and doxycycline 12.5%, respectively. According to the contingency coefficient test, there was moderate correlation between the resistance pattern of P. acnes to clindamycin (r = 0.485, P = <0.001) and doxycycline (r = 0.433, P = 0.002) and AV severity. There was weak correlation between the resistance pattern of P. acnes to erythromycin (r = 0.333; P = 0.025) and azithromycin (r = 0.321; P = 0.032) and AV severity. In conclusion, there is a correlation between the pattern of P. acnes resistance to doxycycline, clindamycin, erythromycin, azithromycin and severity of AV.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=4;spage=488;epage=488;aulast=Gozaliacne vulgarisantibioticantimicrobial resistancepropionibacterium acnes |
| spellingShingle | Maria Mayfinna Gozali Yuli Kurniawati Mutia Devi Erial Bahar Lisa Dewi Yulia Farida Yahya Rusmawardiana Sarah Diba Zulkarnain Soenarto Kartowigno Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital Indian Journal of Dermatology acne vulgaris antibiotic antimicrobial resistance propionibacterium acnes |
| title | Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital |
| title_full | Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital |
| title_fullStr | Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital |
| title_full_unstemmed | Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital |
| title_short | Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital |
| title_sort | correlation between antimicrobial resistant propionibacterium acnes and severity of acne vulgaris findings from a tertiary hospital |
| topic | acne vulgaris antibiotic antimicrobial resistance propionibacterium acnes |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=4;spage=488;epage=488;aulast=Gozali |
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