Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus
Rong Shi, Zheyun Niu, Birong Wu, Fan Hu School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Fan Hu Tel/Fax +86 2151322466Email joyking2003@163.comPurpose: The study aimed to identify diseases that exhibit signifi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Risk Management and Healthcare Policy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/study-on-the-risk-factors-for-hyperuricaemia-and-related-vascular-comp-peer-reviewed-article-RMHP |
| _version_ | 1818301221096652800 |
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| author | Shi R Niu Z Wu B Hu F |
| author_facet | Shi R Niu Z Wu B Hu F |
| author_sort | Shi R |
| collection | DOAJ |
| description | Rong Shi, Zheyun Niu, Birong Wu, Fan Hu School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Fan Hu Tel/Fax +86 2151322466Email joyking2003@163.comPurpose: The study aimed to identify diseases that exhibit significant differences between hyperuricaemia (HUA) and non-hyperuricaemia (NHUA) groups and analyse the risk factors for HUA based on the related diseases in type 2 diabetes mellitus (T2DM).Methods: A total of 3264 T2DM patients were investigated from 2013 to 2017 in the Jinyang and Sanlin communities by obtaining basic data from the electronic medical record system (EMRS). From September 2018 to July 2019, 3000 patients (264 patients were missing during follow-up) were investigated with questionnaires, physical examinations and biochemical index tests. After removing missing values, 2899 patients were divided into HUA and NHUA groups. The chi-square test was used to identify diseases with differences. Using Lasso analysis and logistic regression analysis, risk factors for HUA based on the related diseases were obtained. The C-index, receiver operating characteristic (ROC) curve and calibration plot were used to validate the discrimination and accuracy of the factors.Results: The chi-square test showed that there were significant differences in coronary heart disease (CHD) and diabetic nephropathy (DN) between the HUA group and the NHUA group. Through Lasso regression, glycosylated haemoglobin A1c (HbA1c), triglyceride (TG), blood urea nitrogen (BUN) and serum creatinine (SCR) were screened in the CHD group. Body mass index (BMI), HbA1c, total cholesterol (TC), TG, BUN, SCR and urine microalbumin (UMA) were screened in the DN group. The P-value of all the variables was less than 0.05. Through the C-index, calibration, and ROC curve analyses, these risk factors had medium accuracy.Conclusion: HUA was significantly related to CHD and DN. The level of UA was correlated with HbA1c, TG, BUN, and SCR based on CHD. The level of UA was associated with BMI, HbA1c, TC, TG, BUN, SCR, and UMA based on DN.Keywords: hyperuricaemia, complications, risk factors, type 2 diabetes mellitus |
| first_indexed | 2024-12-13T05:19:34Z |
| format | Article |
| id | doaj.art-60c302ca57024061b48cc4f2c078a301 |
| institution | Directory Open Access Journal |
| issn | 1179-1594 |
| language | English |
| last_indexed | 2024-12-13T05:19:34Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Risk Management and Healthcare Policy |
| spelling | doaj.art-60c302ca57024061b48cc4f2c078a3012022-12-21T23:58:22ZengDove Medical PressRisk Management and Healthcare Policy1179-15942020-09-01Volume 131661167557197Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes MellitusShi RNiu ZWu BHu FRong Shi, Zheyun Niu, Birong Wu, Fan Hu School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Fan Hu Tel/Fax +86 2151322466Email joyking2003@163.comPurpose: The study aimed to identify diseases that exhibit significant differences between hyperuricaemia (HUA) and non-hyperuricaemia (NHUA) groups and analyse the risk factors for HUA based on the related diseases in type 2 diabetes mellitus (T2DM).Methods: A total of 3264 T2DM patients were investigated from 2013 to 2017 in the Jinyang and Sanlin communities by obtaining basic data from the electronic medical record system (EMRS). From September 2018 to July 2019, 3000 patients (264 patients were missing during follow-up) were investigated with questionnaires, physical examinations and biochemical index tests. After removing missing values, 2899 patients were divided into HUA and NHUA groups. The chi-square test was used to identify diseases with differences. Using Lasso analysis and logistic regression analysis, risk factors for HUA based on the related diseases were obtained. The C-index, receiver operating characteristic (ROC) curve and calibration plot were used to validate the discrimination and accuracy of the factors.Results: The chi-square test showed that there were significant differences in coronary heart disease (CHD) and diabetic nephropathy (DN) between the HUA group and the NHUA group. Through Lasso regression, glycosylated haemoglobin A1c (HbA1c), triglyceride (TG), blood urea nitrogen (BUN) and serum creatinine (SCR) were screened in the CHD group. Body mass index (BMI), HbA1c, total cholesterol (TC), TG, BUN, SCR and urine microalbumin (UMA) were screened in the DN group. The P-value of all the variables was less than 0.05. Through the C-index, calibration, and ROC curve analyses, these risk factors had medium accuracy.Conclusion: HUA was significantly related to CHD and DN. The level of UA was correlated with HbA1c, TG, BUN, and SCR based on CHD. The level of UA was associated with BMI, HbA1c, TC, TG, BUN, SCR, and UMA based on DN.Keywords: hyperuricaemia, complications, risk factors, type 2 diabetes mellitushttps://www.dovepress.com/study-on-the-risk-factors-for-hyperuricaemia-and-related-vascular-comp-peer-reviewed-article-RMHPhyperuricaemiacomplicationsrisk factorstype 2 diabetes mellitus |
| spellingShingle | Shi R Niu Z Wu B Hu F Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus Risk Management and Healthcare Policy hyperuricaemia complications risk factors type 2 diabetes mellitus |
| title | Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus |
| title_full | Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus |
| title_short | Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus |
| title_sort | study on the risk factors for hyperuricaemia and related vascular complications in patients with type 2 diabetes mellitus |
| topic | hyperuricaemia complications risk factors type 2 diabetes mellitus |
| url | https://www.dovepress.com/study-on-the-risk-factors-for-hyperuricaemia-and-related-vascular-comp-peer-reviewed-article-RMHP |
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