Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water
Phosphorylation under plausible prebiotic conditions continues to be one of the defining issues for the role of phosphorus in the origins of life processes. In this review, we cover the reactions of alternative forms of phosphate, specifically the nitrogenous versions of phosphate (and other forms o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/7/3/32 |
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| author | Megha Karki Clémentine Gibard Subhendu Bhowmik Ramanarayanan Krishnamurthy |
| author_facet | Megha Karki Clémentine Gibard Subhendu Bhowmik Ramanarayanan Krishnamurthy |
| author_sort | Megha Karki |
| collection | DOAJ |
| description | Phosphorylation under plausible prebiotic conditions continues to be one of the defining issues for the role of phosphorus in the origins of life processes. In this review, we cover the reactions of alternative forms of phosphate, specifically the nitrogenous versions of phosphate (and other forms of reduced phosphorus species) from a prebiotic, synthetic organic and biochemistry perspective. The ease with which such amidophosphates or phosphoramidate derivatives phosphorylate a wide variety of substrates suggests that alternative forms of phosphate could have played a role in overcoming the “phosphorylation in water problem”. We submit that serious consideration should be given to the search for primordial sources of nitrogenous versions of phosphate and other versions of phosphorus. |
| first_indexed | 2024-04-11T22:16:20Z |
| format | Article |
| id | doaj.art-60cdc2345e3242fab4fb14771a35031f |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-04-11T22:16:20Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-60cdc2345e3242fab4fb14771a35031f2022-12-22T04:00:23ZengMDPI AGLife2075-17292017-07-01733210.3390/life7030032life7030032Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in WaterMegha Karki0Clémentine Gibard1Subhendu Bhowmik2Ramanarayanan Krishnamurthy3Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USADepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USADepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USADepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USAPhosphorylation under plausible prebiotic conditions continues to be one of the defining issues for the role of phosphorus in the origins of life processes. In this review, we cover the reactions of alternative forms of phosphate, specifically the nitrogenous versions of phosphate (and other forms of reduced phosphorus species) from a prebiotic, synthetic organic and biochemistry perspective. The ease with which such amidophosphates or phosphoramidate derivatives phosphorylate a wide variety of substrates suggests that alternative forms of phosphate could have played a role in overcoming the “phosphorylation in water problem”. We submit that serious consideration should be given to the search for primordial sources of nitrogenous versions of phosphate and other versions of phosphorus.https://www.mdpi.com/2075-1729/7/3/32prebiotic phosphorylationnitrogen-phosphorus derivativesphosphoramidates(di)amidophosphateorigins of life |
| spellingShingle | Megha Karki Clémentine Gibard Subhendu Bhowmik Ramanarayanan Krishnamurthy Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water Life prebiotic phosphorylation nitrogen-phosphorus derivatives phosphoramidates (di)amidophosphate origins of life |
| title | Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water |
| title_full | Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water |
| title_fullStr | Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water |
| title_full_unstemmed | Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water |
| title_short | Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water |
| title_sort | nitrogenous derivatives of phosphorus and the origins of life plausible prebiotic phosphorylating agents in water |
| topic | prebiotic phosphorylation nitrogen-phosphorus derivatives phosphoramidates (di)amidophosphate origins of life |
| url | https://www.mdpi.com/2075-1729/7/3/32 |
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