3-Aryl-4-nitrobenzothiochromans <i>S,S</i>-dioxide: From Calcium-Channel Modulators Properties to Multidrug-Resistance Reverting Activity

3-Aryl-4-nitrobenzothiochromans <i>S,S</i>-dioxide: From Calcium-Channel Modulators Properties to Multidrug-Resistance Reverting Activity

Our research groups have been involved for many years in studies aimed at identifying new active organic compounds endowed with pharmacological properties. In this work, we focused our attention on the evaluation of cardiovascular and molecular drug resistance (MDR) reverting activities of some nitr...

Full description

Bibliographic Details
Main Authors:	Matteo Micucci, Maurizio Viale, Alberto Chiarini, Domenico Spinelli, Maria Frosini, Cinzia Tavani, Massimo Maccagno, Lara Bianchi, Rosaria Gangemi, Roberta Budriesi
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Molecules
Subjects:	3-aryl-4-nitrothiochromans <i>s</i>,<i>s</i>-dioxide <span style="font-variant: small-caps">l</span>-type calcium channels (ltcc) anticancer therapy multidrug resistance (mdr1) in vitro experiments cardiovascular activity
Online Access:	https://www.mdpi.com/1420-3049/25/5/1056

Similar Items

Mild Copper-Catalyzed, <span style="font-variant: small-caps">l</span>-Proline-Promoted Cross-Coupling of Methyl 3-Amino-1-benzothiophene-2-carboxylate
by: Vilija Kederienė, et al.
Published: (2021-11-01)

Characterization of <span style="font-variant: small-caps">l</span>-Arabinose Isomerase from <i>Klebsiella pneumoniae</i> and Its Application in the Production of <span style="font-variant: small-caps">d</span>-Tagatose from <span style="font-variant: small-caps">d</span>-Galactose
by: Kyung-Chul Shin, et al.
Published: (2022-05-01)

Microbial Production Potential of <i>Pantoea ananatis</i>: From Amino Acids to Secondary Metabolites
by: Yoshihiro Usuda, et al.
Published: (2022-05-01)

The Application of <i>Corynebacterium glutamicum</i> in <span style="font-variant: small-caps">l</span>-Threonine Biosynthesis
by: Min Duan, et al.
Published: (2023-09-01)

Cyclo(<span style="font-variant: small-caps">l</span>-Pro–<span style="font-variant: small-caps">l</span>-Leu) of <i>Pseudomonas putida</i> MCCC 1A00316 Isolated from Antarctic Soil: Identification and Characterization of Activity against <i>Meloidogyne incognita</i>
by: Yile Zhai, et al.
Published: (2019-02-01)

The Arginine Catabolism-Derived Amino Acid <span style="font-variant: small-caps">l</span>-ornithine Is a Chemoattractant for <i>Pseudomonas aeruginosa</i>
by: Basanta Dhodary, et al.
Published: (2022-01-01)

Regulation of <span style="font-variant: small-caps">d</span>-Aspartate Oxidase Gene Expression by Pyruvate Metabolism in the Yeast <i>Cryptococcus humicola</i>
by: Daiki Imanishi, et al.
Published: (2021-11-01)

Fermented Wild Ginseng by <i>Rhizopus oligosporus</i> Improved <span style="font-variant: small-caps">l</span>-Carnitine and Ginsenoside Contents
by: Ganghee Lee, et al.
Published: (2020-04-01)

An LC-MS/MS Method to Measure <i>S</i>-Methyl-<span style="font-variant: small-caps">l</span>-Cysteine and <i>S</i>-Methyl-<span style="font-variant: small-caps">l</span>-Cysteine Sulfoxide in Human Specimens Using Isotope Labelled Internal Standards
by: Tharsini Sivapalan, et al.
Published: (2019-07-01)

Isolation, Characterization and Chemical Synthesis of Large Spectrum Antimicrobial Cyclic Dipeptide (<span style="font-variant: small-caps">l</span>-leu-<span style="font-variant: small-caps">l</span>-pro) from <i>Streptomyces misionensis</i> V16R3Y1 Bacteria Extracts. A Novel <sup>1</sup>H NMR Metabolomic Approach
by: Ilhem Saadouli, et al.
Published: (2020-05-01)

Effects of Decomplexation Rates on Ternary Gene Complex Transfection with <i>α</i>-Poly(<span style="font-variant: small-caps">l</span>-Lysine) or <i>ε</i>-Poly(<span style="font-variant: small-caps">l</span>-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell
by: Kyoungnam Kim, et al.
Published: (2020-05-01)

Screening for the Active Anti-Inflammatory and Antioxidant Polyphenols of <i>Gaultheria procumbens</i> and Their Application for Standardisation: From Identification through Cellular Studies to Quantitative Determination
by: Monika Anna Olszewska, et al.
Published: (2021-10-01)

Identification of an Acidic Amino Acid Permease Involved in <span style="font-variant: small-caps">d-</span>Aspartate Uptake in the Yeast <i>Cryptococcus humicola</i>
by: Daiki Imanishi, et al.
Published: (2021-01-01)

Effect of <i>N</i>-acetyl-<span style="font-variant: small-caps">l</span>-cysteine on Cell Phenotype and Autophagy in <i>Pichia pastoris</i> Expressing Human Serum Albumin and Porcine Follicle-Stimulating Hormone Fusion Protein
by: Yingqing Xu, et al.
Published: (2023-03-01)

The <span style="font-variant: small-caps">KERES</span> Ontology: Protecting Cultural Heritage from Extreme Climate Events
by: Jürgen Reuter, et al.
Published: (2023-04-01)

Defense Mechanisms Induced by Celery Seed Essential Oil against Powdery Mildew Incited by <i>Podosphaera fusca</i> in Cucumber
by: Hajar Soleimani, et al.
Published: (2023-12-01)

Simultaneous Determination of Four Marker Compounds in <i>Lobelia chinensis</i> Lour. Extract by HPLC-PDA
by: Beom-Geun Jo, et al.
Published: (2021-12-01)

Identification of the Aldo-Keto Reductase Responsible for <span style="font-variant: small-caps">d</span>-Galacturonic Acid Conversion to <span style="font-variant: small-caps">l</span>-Galactonate in <i>Saccharomyces cerevisiae</i>
by: Dorthe Rippert, et al.
Published: (2021-10-01)

Production of <span style="font-variant: small-caps">d</span>-Tagatose by Whole-Cell Conversion of Recombinant <i>Bacillus subtilis</i> in the Absence of Antibiotics
by: Xian Zhang, et al.
Published: (2021-12-01)

<span style="font-variant: small-caps;">l</span>-Fucose Synthesis Using a Halo- and Thermophilic <span style="font-variant: small-caps;">l</span>-Fucose Isomerase from Polyextremophilic <em>Halothermothrix orenii</em>
by: In Jung Kim, et al.
Published: (2022-04-01)

Biocatalysis of Fucodian in <i>Undaria pinnatifida</i> Sporophyll Using <i>Bifidobacterium longum</i> RD47 for Production of Prebiotic Fucosylated Oligosaccharide
by: Jeong Min Lee, et al.
Published: (2019-02-01)

Recent Advances in the Preparation, Structure, and Biological Activities of β-Glucan from <i>Ganoderma</i> Species: A Review
by: Henan Zhang, et al.
Published: (2023-08-01)

Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (<i>Juglans nigra</i>) Using a High-Throughput Screening Approach
by: Khanh-Van Ho, et al.
Published: (2020-10-01)

<i>Bacteroides thetaiotaomicron</i> Fosters the Growth of Butyrate-Producing <i>Anaerostipes caccae</i> in the Presence of Lactose and Total Human Milk Carbohydrates
by: Loo Wee Chia, et al.
Published: (2020-10-01)

<span style="font-variant: small-caps">l</span>-Asparaginase Type II from <i>Fusarium proliferatum</i>: Heterologous Expression and In Silico Analysis
by: Samuel Leite Cardoso, et al.
Published: (2023-09-01)

Diagnostic Performance of Bronchoalveolar Lavage (1,3)-β-<span style="font-variant: small-caps">d</span>-Glucan Assay for <i>Pneumocystis jirovecii</i> Pneumonia
by: Shiwei Zhou, et al.
Published: (2020-10-01)

How the Neurotoxin β-<i>N</i>-Methylamino-<span style="font-variant: small-caps">l</span>-Alanine Accumulates in Bivalves: Distribution of the Different Accumulation Fractions among Organs
by: Alexandra Lepoutre, et al.
Published: (2020-01-01)

The Healing-Promoting Properties of Selected Cyclitols—A Review
by: Agnieszka Owczarczyk-Saczonek, et al.
Published: (2018-12-01)

Functional Characterization of Endo- and Exo-Hydrolase Genes in Arabinan Degradation Gene Cluster of <i>Bifidobacterium longum</i> subsp. <i>suis</i>
by: Yewon Kang, et al.
Published: (2024-03-01)

Transcriptional Activation of <i>Chac1</i> and Other Atf4-Target Genes Induced by Extracellular <span style="font-variant: small-caps">l</span>-Serine Depletion is negated with Glycine Consumption in Hepa1-6 Hepatocarcinoma Cells
by: Momoko Hamano, et al.
Published: (2020-10-01)

Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant, <i><span style="font-variant: small-caps">N</span></i>-Acetyl-<span style="font-variant: small-caps">l</span>-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death
by: Dae Ki Hong, et al.
Published: (2020-08-01)

<span style="font-variant: small-caps">d</span>-Cysteine-Induced Rapid Root Abscission in the Water Fern <i>Azolla Pinnata</i>: Implications for the Linkage between <span style="font-variant: small-caps">d</span>-Amino Acid and Reactive Sulfur Species (RSS) in Plant Environmental Responses
by: Hideo Yamasaki, et al.
Published: (2019-09-01)

A Combination of Structural, Genetic, Phenotypic and Enzymatic Analyses Reveals the Importance of a Predicted Fucosyltransferase to Protein <i>O</i>-Glycosylation in the Bacteroidetes
by: Markus B. Tomek, et al.
Published: (2021-11-01)

Hepatocyte-Specific <i>Phgdh</i>-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation
by: Momoko Hamano, et al.
Published: (2021-09-01)

Novel Lytic Enzyme of Prophage Origin from <i>Clostridium botulinum</i> E3 Strain Alaska E43 with Bactericidal Activity against Clostridial Cells
by: Agnieszka Morzywolek, et al.
Published: (2021-09-01)

Evaluation of Physicochemical Properties of a Hydrocolloid-Based Functional Food Fortified with <i>Caulerpa lentillifera</i>: A D-Optimal Design Approach
by: Nor Atikah Husna Ahmad Nasir, et al.
Published: (2023-06-01)

Bacterial Cell Wall Analogue Peptides Control the Oligomeric States and Activity of the Glycopeptide Antibiotic Eremomycin: Solution NMR and Antimicrobial Studies
by: László Izsépi, et al.
Published: (2021-01-01)

Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions
by: Motohiro Okada, et al.
Published: (2019-11-01)

Ameliorative Potential of Hydroethanolic Leaf Extract of <i>Parquetina nigrescens</i> on <span style="font-variant: small-caps">d</span>-Galactose-Induced Testicular Injury
by: Lydia Ajayi, et al.
Published: (2021-06-01)

Characterization of Two α-<span style="font-variant: small-caps">l</span>-Arabinofuranosidases from <i>Acetivibrio mesophilus</i> and Their Synergistic Effect in Degradation of Arabinose-Containing Substrates
by: Yajing Liu, et al.
Published: (2021-07-01)