Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report
ABSTRACT Immunomediated thrombocytopenia is a systemic metabolic disorder in which the platelet count falls below reference values, as the patient's immune system destroys them. The main clinical signs in thrombocytopenia are petechial, hemorrhages, ecchymoses and suffusions. Hematomas can also...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal de Minas Gerais
2023-04-01
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| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000200221&lng=en&tlng=en |
| _version_ | 1797844864029687808 |
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| author | P.R. Santi M.R. França M. Milistetd |
| author_facet | P.R. Santi M.R. França M. Milistetd |
| author_sort | P.R. Santi |
| collection | DOAJ |
| description | ABSTRACT Immunomediated thrombocytopenia is a systemic metabolic disorder in which the platelet count falls below reference values, as the patient's immune system destroys them. The main clinical signs in thrombocytopenia are petechial, hemorrhages, ecchymoses and suffusions. Hematomas can also occur in coagulation disorders. The diagnosis is based on clinical findings and hematological examinations. The treatment consists of the use of corticosteroids and immunosuppressants, delaying cell destruction, and may last for months, not always obtaining a cure for the disease. The present work reports the use of therapy with allogeneic mesenchymal stem cells, derived from the adipose tissue of dogs, for the treatment of chronic immunomediated thrombocytopenia, with an evolution of more than one year, in a Pinscher dog. The alternative treatment showed a good evolution, keeping platelets within the reference values during the treatment, giving the patient quality of life and removing the need for continuous medication for homeostasis after treatment. |
| first_indexed | 2024-04-09T17:29:15Z |
| format | Article |
| id | doaj.art-60ce5c30776d4575a8ddb3bbf806b3e4 |
| institution | Directory Open Access Journal |
| issn | 1678-4162 |
| language | English |
| last_indexed | 2024-04-09T17:29:15Z |
| publishDate | 2023-04-01 |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj.art-60ce5c30776d4575a8ddb3bbf806b3e42023-04-18T07:33:14ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-41622023-04-0175222122610.1590/1678-4162-12445Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case reportP.R. Santihttps://orcid.org/0000-0002-6575-3279M.R. Françahttps://orcid.org/0000-0002-8560-9303M. Milistetdhttps://orcid.org/0000-0003-3818-0054ABSTRACT Immunomediated thrombocytopenia is a systemic metabolic disorder in which the platelet count falls below reference values, as the patient's immune system destroys them. The main clinical signs in thrombocytopenia are petechial, hemorrhages, ecchymoses and suffusions. Hematomas can also occur in coagulation disorders. The diagnosis is based on clinical findings and hematological examinations. The treatment consists of the use of corticosteroids and immunosuppressants, delaying cell destruction, and may last for months, not always obtaining a cure for the disease. The present work reports the use of therapy with allogeneic mesenchymal stem cells, derived from the adipose tissue of dogs, for the treatment of chronic immunomediated thrombocytopenia, with an evolution of more than one year, in a Pinscher dog. The alternative treatment showed a good evolution, keeping platelets within the reference values during the treatment, giving the patient quality of life and removing the need for continuous medication for homeostasis after treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000200221&lng=en&tlng=enplateletsautoimmunemultipotentstem cells |
| spellingShingle | P.R. Santi M.R. França M. Milistetd Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report Arquivo Brasileiro de Medicina Veterinária e Zootecnia platelets autoimmune multipotent stem cells |
| title | Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report |
| title_full | Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report |
| title_fullStr | Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report |
| title_full_unstemmed | Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report |
| title_short | Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog - case report |
| title_sort | treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog case report |
| topic | platelets autoimmune multipotent stem cells |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352023000200221&lng=en&tlng=en |
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