The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study
Objective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregn...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1334 |
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| author | Huanrong Li Meilu Lyu Ruqian Zhao Yuqin Zang Pengzhu Huang Jie Li Ye Yan Yingmei Wang Zengyan Li Cha Han Fengxia Xue |
| author_facet | Huanrong Li Meilu Lyu Ruqian Zhao Yuqin Zang Pengzhu Huang Jie Li Ye Yan Yingmei Wang Zengyan Li Cha Han Fengxia Xue |
| author_sort | Huanrong Li |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student’s <i>t</i>-test or Wilcoxon rank-sum test. Categorical variables were analyzed using the Chi-square test. The risk factors of twin pregnancies with preeclampsia were analyzed by logistic regression. Results: The rate of twin pregnancy complicated by preeclampsia was 17.62% (123/698). Logistic regression analysis showed that ART increased the risk of preeclampsia in twin pregnancies (AOR: 1.868, 95% CI: 1.187–2.941). Mothers with preeclampsia carrying twins conceived with ART had a higher rate of delivery at gestational week < 34 (29.9% vs. 12.5%) and asphyxia of the neonate at 5 min after delivery (13.4% vs. 1.8%) than those with preeclampsia conceived without ART (<i>p</i> < 0.05). Conclusions: ART increases the risk of preeclampsia in twin pregnancies and the rate of adverse maternal–neonatal outcomes for twin pregnancies with preeclampsia. The policy of single embryo transfer is a method to reduce the adverse pregnancy outcomes of ART. |
| first_indexed | 2024-03-10T00:01:17Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
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| publishDate | 2022-05-01 |
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| series | Diagnostics |
| spelling | doaj.art-60cea9c9f94a4098bc3aca79ba962dff2023-11-23T16:16:24ZengMDPI AGDiagnostics2075-44182022-05-01126133410.3390/diagnostics12061334The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective StudyHuanrong Li0Meilu Lyu1Ruqian Zhao2Yuqin Zang3Pengzhu Huang4Jie Li5Ye Yan6Yingmei Wang7Zengyan Li8Cha Han9Fengxia Xue10Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaObjective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student’s <i>t</i>-test or Wilcoxon rank-sum test. Categorical variables were analyzed using the Chi-square test. The risk factors of twin pregnancies with preeclampsia were analyzed by logistic regression. Results: The rate of twin pregnancy complicated by preeclampsia was 17.62% (123/698). Logistic regression analysis showed that ART increased the risk of preeclampsia in twin pregnancies (AOR: 1.868, 95% CI: 1.187–2.941). Mothers with preeclampsia carrying twins conceived with ART had a higher rate of delivery at gestational week < 34 (29.9% vs. 12.5%) and asphyxia of the neonate at 5 min after delivery (13.4% vs. 1.8%) than those with preeclampsia conceived without ART (<i>p</i> < 0.05). Conclusions: ART increases the risk of preeclampsia in twin pregnancies and the rate of adverse maternal–neonatal outcomes for twin pregnancies with preeclampsia. The policy of single embryo transfer is a method to reduce the adverse pregnancy outcomes of ART.https://www.mdpi.com/2075-4418/12/6/1334assisted reproductive technologyoutcomespreeclampsiatwin pregnancies |
| spellingShingle | Huanrong Li Meilu Lyu Ruqian Zhao Yuqin Zang Pengzhu Huang Jie Li Ye Yan Yingmei Wang Zengyan Li Cha Han Fengxia Xue The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study Diagnostics assisted reproductive technology outcomes preeclampsia twin pregnancies |
| title | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
| title_full | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
| title_fullStr | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
| title_full_unstemmed | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
| title_short | The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study |
| title_sort | maternal neonatal outcomes of twin pregnancies with preeclampsia and their association with assisted reproductive technology a retrospective study |
| topic | assisted reproductive technology outcomes preeclampsia twin pregnancies |
| url | https://www.mdpi.com/2075-4418/12/6/1334 |
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