l-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata

l-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata

l-DOPA treatment induces abnormal involuntary movements (AIMs) in Parkinson's patients and experimental animals. We examined the relationship between the development of AIMs (dyskinesia) and changes in [3H]-GABA release and cAMP signaling in striatonigral terminals of rats with unilateral 6-OHD...

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Bibliographic Details
Main Authors: Claudia Rangel-Barajas, Isaac Silva, Luz María Lopéz-Santiago, Jorge Aceves, David Erlij, Benjamín Florán
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Neurobiology of Disease
Subjects:
l-DOPA
Basal ganglia
GABA release
cAMP
Hemiparkinsonism
Substantia nigra
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002779

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