Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden
Background Effectiveness estimates from observational studies on ticagrelor use in routine clinical care are conflicting, with some contrary to the results of the pivotal randomized controlled trial of ticagrelor in acute coronary syndrome. The aim of this study was to estimate the effect of impleme...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.027384 |
| _version_ | 1797290401769455616 |
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| author | Kasper Johannesen Jonathan Siverskog Martin Henriksson Magnus Janzon Bertil Lindahl Erik Grönqvist |
| author_facet | Kasper Johannesen Jonathan Siverskog Martin Henriksson Magnus Janzon Bertil Lindahl Erik Grönqvist |
| author_sort | Kasper Johannesen |
| collection | DOAJ |
| description | Background Effectiveness estimates from observational studies on ticagrelor use in routine clinical care are conflicting, with some contrary to the results of the pivotal randomized controlled trial of ticagrelor in acute coronary syndrome. The aim of this study was to estimate the effect of implementing and using ticagrelor in routine clinical care in patients with myocardial infarction using a natural experimental approach. Methods and Results This is a retrospective cohort study including patients hospitalized for myocardial infarction in Sweden between 2009 and 2015. The study exploited differences in the timing and speed of ticagrelor implementation between treatment centers as a source of random treatment assignment. The effect of implementing and using ticagrelor was estimated based on the admitting center's likelihood of treating patients with ticagrelor, measured as the proportion of patients treated in the 90 days before patient admission. The main outcome was 12‐month mortality. The study included 109 955 patients, of whom 30 773 were treated with ticagrelor. Being admitted to a treatment center with higher past ticagrelor use was associated with a reduction in 12‐month mortality (2.5 percentage points for 100% versus 0% past use [95% CI, 0.2–4.8]). The results are in line with the findings from the ticagrelor pivotal trial. Conclusions Using a natural experiment, this study finds that the implementation and use of ticagrelor in routine clinical care has reduced 12‐month mortality in patients admitted to the hospital with myocardial infarction in Sweden and supports the external validity of randomized evidence on ticagrelor effectiveness. |
| first_indexed | 2024-03-07T19:21:51Z |
| format | Article |
| id | doaj.art-60d30ede87ca4f9dbb061299d621b10e |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-07T19:21:51Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-60d30ede87ca4f9dbb061299d621b10e2024-02-29T10:25:12ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-03-0112510.1161/JAHA.122.027384Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in SwedenKasper Johannesen0Jonathan Siverskog1Martin Henriksson2Magnus Janzon3Bertil Lindahl4Erik Grönqvist5Centre for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences Linköping University Linköping SwedenCentre for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences Linköping University Linköping SwedenCentre for Medical Technology Assessment, Department of Health, Medicine and Caring Sciences Linköping University Linköping SwedenDepartment of Cardiology University Hospital Linköping SwedenCentre for Health Economic Research Uppsala University Uppsala SwedenCentre for Health Economic Research Uppsala University Uppsala SwedenBackground Effectiveness estimates from observational studies on ticagrelor use in routine clinical care are conflicting, with some contrary to the results of the pivotal randomized controlled trial of ticagrelor in acute coronary syndrome. The aim of this study was to estimate the effect of implementing and using ticagrelor in routine clinical care in patients with myocardial infarction using a natural experimental approach. Methods and Results This is a retrospective cohort study including patients hospitalized for myocardial infarction in Sweden between 2009 and 2015. The study exploited differences in the timing and speed of ticagrelor implementation between treatment centers as a source of random treatment assignment. The effect of implementing and using ticagrelor was estimated based on the admitting center's likelihood of treating patients with ticagrelor, measured as the proportion of patients treated in the 90 days before patient admission. The main outcome was 12‐month mortality. The study included 109 955 patients, of whom 30 773 were treated with ticagrelor. Being admitted to a treatment center with higher past ticagrelor use was associated with a reduction in 12‐month mortality (2.5 percentage points for 100% versus 0% past use [95% CI, 0.2–4.8]). The results are in line with the findings from the ticagrelor pivotal trial. Conclusions Using a natural experiment, this study finds that the implementation and use of ticagrelor in routine clinical care has reduced 12‐month mortality in patients admitted to the hospital with myocardial infarction in Sweden and supports the external validity of randomized evidence on ticagrelor effectiveness.https://www.ahajournals.org/doi/10.1161/JAHA.122.027384acute coronary syndromeantiplatelet therapymortalitynatural experimentticagrelor |
| spellingShingle | Kasper Johannesen Jonathan Siverskog Martin Henriksson Magnus Janzon Bertil Lindahl Erik Grönqvist Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease acute coronary syndrome antiplatelet therapy mortality natural experiment ticagrelor |
| title | Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden |
| title_full | Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden |
| title_fullStr | Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden |
| title_full_unstemmed | Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden |
| title_short | Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden |
| title_sort | implementation of ticagrelor reduced mortality in routine clinical care evidence from a natural experiment including 109 995 patients with myocardial infarction in sweden |
| topic | acute coronary syndrome antiplatelet therapy mortality natural experiment ticagrelor |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.027384 |
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