A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15427 |
| _version_ | 1818754024780857344 |
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| author | Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri |
| author_facet | Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri |
| author_sort | Tetsuro Yoshimaru |
| collection | DOAJ |
| description | BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner. |
| first_indexed | 2024-12-18T05:16:41Z |
| format | Article |
| id | doaj.art-60d347e4facc4c32a918af21f2d88d68 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:16:41Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-60d347e4facc4c32a918af21f2d88d682022-12-21T21:19:45ZengNature PortfolioNature Communications2041-17232017-05-018111210.1038/ncomms15427A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cellsTetsuro Yoshimaru0Masaya Ono1Yoshimi Bando2Yi-An Chen3Kenji Mizuguchi4Hiroshi Shima5Masato Komatsu6Issei Imoto7Keisuke Izumi8Junko Honda9Yasuo Miyoshi10Mitsunori Sasa11Toyomasa Katagiri12Division of Genome Medicine, Institute for Genome Research, Tokushima UniversityDivision of Chemotherapy and Clinical Research, National Cancer Center Research InstituteDivision of Pathology, Tokushima University HospitalNational Institutes of Biomedical Innovation, Health and NutritionNational Institutes of Biomedical Innovation, Health and NutritionDivision of Cancer Chemotherapy, Miyagi Cancer Center Research InstituteDivision of Genome Medicine, Institute for Genome Research, Tokushima UniversityDepartment of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Molecular and Environmental Pathology, Graduate School of Medicine, Tokushima University Graduate SchoolDepartment of Surgery, National Hospital Organization Higashitokushima Medical CenterDepartment of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of MedicineDepartment of Surgery, Tokushima Breast Care ClinicDivision of Genome Medicine, Institute for Genome Research, Tokushima UniversityBIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.https://doi.org/10.1038/ncomms15427 |
| spellingShingle | Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells Nature Communications |
| title | A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells |
| title_full | A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells |
| title_fullStr | A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells |
| title_full_unstemmed | A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells |
| title_short | A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells |
| title_sort | a kinase anchoring protein big3 coordinates oestrogen signalling in breast cancer cells |
| url | https://doi.org/10.1038/ncomms15427 |
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