Transcriptional Regulation of Macrophages Polarization by MicroRNAs
Diversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage. Macrophages undergo classical M1 or alternative M2 activation in response to the microenvironment signals. Several transcription factors, such as peroxisome proliferator-activated receptors, signal transducers...
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01175/full |
| _version_ | 1819291998399496192 |
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| author | Heng Li Ting Jiang Meng-Qi Li Xi-Long Zheng Xi-Long Zheng Guo-Jun Zhao Guo-Jun Zhao |
| author_facet | Heng Li Ting Jiang Meng-Qi Li Xi-Long Zheng Xi-Long Zheng Guo-Jun Zhao Guo-Jun Zhao |
| author_sort | Heng Li |
| collection | DOAJ |
| description | Diversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage. Macrophages undergo classical M1 or alternative M2 activation in response to the microenvironment signals. Several transcription factors, such as peroxisome proliferator-activated receptors, signal transducers and activators of transcription, CCAAT-enhancer-binding proteins, interferon regulatory factors, Kruppel-like factors, GATA binding protein 3, nuclear transcription factor-κB, and c-MYC, were found to promote the expression of specific genes, which dictate the functional polarization of macrophages. Importantly, these transcription factors can be regulated by microRNAs (miRNAs), a group of small non-coding RNAs, which regulate gene expression through translation repression or mRNA degradation. Recent studies have also revealed that miRNAs control macrophage polarization by regulating transcription factors in response to the microenvironment signals. This review will summarize recent progress of miRNAs in the transcriptional regulation of macrophage polarization and provide the insights into the development of macrophage-centered diagnostic and therapeutic strategies. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T03:47:32Z |
| publishDate | 2018-05-01 |
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| spelling | doaj.art-60d5ccdd736749af8018b0e4a0cd200e2022-12-21T17:16:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.01175356221Transcriptional Regulation of Macrophages Polarization by MicroRNAsHeng Li0Ting Jiang1Meng-Qi Li2Xi-Long Zheng3Xi-Long Zheng4Guo-Jun Zhao5Guo-Jun Zhao6The Clinic Medical College, Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Practice Educational, Office of Academic Affairs, Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Histology and Embryology, Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, Calgary, AB, CanadaKey Laboratory of Molecular Targets and Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, ChinaDepartment of Histology and Embryology, Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, Calgary, AB, CanadaDiversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage. Macrophages undergo classical M1 or alternative M2 activation in response to the microenvironment signals. Several transcription factors, such as peroxisome proliferator-activated receptors, signal transducers and activators of transcription, CCAAT-enhancer-binding proteins, interferon regulatory factors, Kruppel-like factors, GATA binding protein 3, nuclear transcription factor-κB, and c-MYC, were found to promote the expression of specific genes, which dictate the functional polarization of macrophages. Importantly, these transcription factors can be regulated by microRNAs (miRNAs), a group of small non-coding RNAs, which regulate gene expression through translation repression or mRNA degradation. Recent studies have also revealed that miRNAs control macrophage polarization by regulating transcription factors in response to the microenvironment signals. This review will summarize recent progress of miRNAs in the transcriptional regulation of macrophage polarization and provide the insights into the development of macrophage-centered diagnostic and therapeutic strategies.https://www.frontiersin.org/article/10.3389/fimmu.2018.01175/fullmicroRNAstranscription factorsmacrophages polarizationtumorimmunity |
| spellingShingle | Heng Li Ting Jiang Meng-Qi Li Xi-Long Zheng Xi-Long Zheng Guo-Jun Zhao Guo-Jun Zhao Transcriptional Regulation of Macrophages Polarization by MicroRNAs Frontiers in Immunology microRNAs transcription factors macrophages polarization tumor immunity |
| title | Transcriptional Regulation of Macrophages Polarization by MicroRNAs |
| title_full | Transcriptional Regulation of Macrophages Polarization by MicroRNAs |
| title_fullStr | Transcriptional Regulation of Macrophages Polarization by MicroRNAs |
| title_full_unstemmed | Transcriptional Regulation of Macrophages Polarization by MicroRNAs |
| title_short | Transcriptional Regulation of Macrophages Polarization by MicroRNAs |
| title_sort | transcriptional regulation of macrophages polarization by micrornas |
| topic | microRNAs transcription factors macrophages polarization tumor immunity |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01175/full |
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