Polarized Anti-Inflammatory Mesenchymal Stem Cells Increase Hippocampal Neurogenesis and Improve Cognitive Function in Aged Mice

Polarized Anti-Inflammatory Mesenchymal Stem Cells Increase Hippocampal Neurogenesis and Improve Cognitive Function in Aged Mice

Age-related decline in cognitive functions is associated with reduced hippocampal neurogenesis caused by changes in the systemic inflammatory milieu. Mesenchymal stem cells (MSC) are known for their immunomodulatory properties. Accordingly, MSC are a leading candidate for cell therapy and can be app...

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Bibliographic Details
Main Authors: Matanel Tfilin, Nikolai Gobshtis, David Fozailoff, Vadim E. Fraifeld, Gadi Turgeman
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells (MSC)
pituitary adenylate cyclase-activating peptide (PACAP)
MSC2
systemic inflammation
aging
cognitive decline
Online Access:https://www.mdpi.com/1422-0067/24/5/4490

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