Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern China
Objective:To analyze the etiology of chest diffuse radiological changes (DRC) in children older than 2 years.MethodsA retrospective study was conducted on a primary cohort of children with DRC underwent high resolution computed tomography (HRCT).ResultsDRC mainly included bronchial wall thickening,...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.823350/full |
| _version_ | 1811301320388247552 |
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| author | Xuefeng Xu Lingke Liu Xuchen Xu Qian Ma Liping Teng Haichun Zhou Li Yang Meiping Lu |
| author_facet | Xuefeng Xu Lingke Liu Xuchen Xu Qian Ma Liping Teng Haichun Zhou Li Yang Meiping Lu |
| author_sort | Xuefeng Xu |
| collection | DOAJ |
| description | Objective:To analyze the etiology of chest diffuse radiological changes (DRC) in children older than 2 years.MethodsA retrospective study was conducted on a primary cohort of children with DRC underwent high resolution computed tomography (HRCT).ResultsDRC mainly included bronchial wall thickening, interlobular septal thickening, pleural thickening, ground glass opacity, mosaic perfusion, reticular & linear opacities, nodular opacity, and tree-in-bud. Of the identified 457 children with DRC, 83 of children older than 2 years with DRC were included in the present study. Ground glass opacity (53, 63.9%) and reticular & linear opacities (44, 53.0%) were frequently identified findings of HRCT, and no tree-in-bud pattern was observed. By contrast, among children with DRC by M. pneumoniae (n = 64), bronchial wall thickening (33, 51.6%), and mosaic perfusion (17, 26.6%) were common patterns of HRCT in addition to ground glass opacity (36, 56.3%). Most of etiologies were connective tissue disease (24, 28.9%), followed by diffuse alveolar hemorrhage syndrome (9, 10.8%), Langerhans cell histiocytosis (7, 8.4%), and recurrent aspiration (6, 7.2%).ConclusionsThis study adds further insights into the role of HRCT in diagnosing childhood interstitial lung diseases, indirectly reflecting disease compositions. |
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| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T07:06:33Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-60d84c9fcdc449c3882b7c7855bbb82a2022-12-22T02:56:59ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-05-011010.3389/fped.2022.823350823350Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern ChinaXuefeng Xu0Lingke Liu1Xuchen Xu2Qian Ma3Liping Teng4Haichun Zhou5Li Yang6Meiping Lu7Department of Rheumatology Immunology and Allergy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Rheumatology Immunology and Allergy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Rheumatology Immunology and Allergy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Rheumatology Immunology and Allergy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Rheumatology Immunology and Allergy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Radiology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Radiology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Rheumatology Immunology and Allergy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaObjective:To analyze the etiology of chest diffuse radiological changes (DRC) in children older than 2 years.MethodsA retrospective study was conducted on a primary cohort of children with DRC underwent high resolution computed tomography (HRCT).ResultsDRC mainly included bronchial wall thickening, interlobular septal thickening, pleural thickening, ground glass opacity, mosaic perfusion, reticular & linear opacities, nodular opacity, and tree-in-bud. Of the identified 457 children with DRC, 83 of children older than 2 years with DRC were included in the present study. Ground glass opacity (53, 63.9%) and reticular & linear opacities (44, 53.0%) were frequently identified findings of HRCT, and no tree-in-bud pattern was observed. By contrast, among children with DRC by M. pneumoniae (n = 64), bronchial wall thickening (33, 51.6%), and mosaic perfusion (17, 26.6%) were common patterns of HRCT in addition to ground glass opacity (36, 56.3%). Most of etiologies were connective tissue disease (24, 28.9%), followed by diffuse alveolar hemorrhage syndrome (9, 10.8%), Langerhans cell histiocytosis (7, 8.4%), and recurrent aspiration (6, 7.2%).ConclusionsThis study adds further insights into the role of HRCT in diagnosing childhood interstitial lung diseases, indirectly reflecting disease compositions.https://www.frontiersin.org/articles/10.3389/fped.2022.823350/fullchildrendiffuse radiological changesetiologyhigh resolution computed tomographyinterstitial lung disease |
| spellingShingle | Xuefeng Xu Lingke Liu Xuchen Xu Qian Ma Liping Teng Haichun Zhou Li Yang Meiping Lu Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern China Frontiers in Pediatrics children diffuse radiological changes etiology high resolution computed tomography interstitial lung disease |
| title | Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern China |
| title_full | Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern China |
| title_fullStr | Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern China |
| title_full_unstemmed | Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern China |
| title_short | Etiologic Profile of Older Children With Diffuse Radiological Changes in Eastern China |
| title_sort | etiologic profile of older children with diffuse radiological changes in eastern china |
| topic | children diffuse radiological changes etiology high resolution computed tomography interstitial lung disease |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.823350/full |
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